Results 121 to 130 of about 2,526,308 (267)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
An integrated approach for modelling of aircraft maintenance processes
Научный вестник МГТУ ГА, 2016 The paper deals with modeling of the processes of maintenance and repair of aircraft. The role of information in im-proving the effectiveness of maintenance systems is described. The methodology for functional modelling of maintenance processes is given.
D. Yu. Kiselev, Yu. V. Kiselev
doaj
Functional model of rat thyroid follicles cultured in Matrigel. [PDF]
Endocr Connect, 2021 Khoruzhenko A +6 more
europepmc +1 more source
Theoretical and Mathematical Physics, 2001 The correlation functions are calculated for the two dimensional Ising model with free boundary conditions and the two dimensional Ising model with periodic boundary conditions.
openaire +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Functional Model for Unifying Brain Computer Interface Terminology. [PDF]
IEEE Open J Eng Med Biol, 2021 Easttom C +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A Functional Model for Structure Learning and Parameter Estimation in Continuous Time Bayesian Network: An Application in Identifying Patterns of Multiple Chronic Conditions. [PDF]
IEEE Access, 2021 Faruqui SHA +4 more
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source