Results 111 to 120 of about 6,409,949 (276)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Video_4_Clinical Characteristics of Functional Movement Disorders in the Stomatognathic System.MP4

, 2020
Background: Functional (psychogenic) movement disorders often have distinguishable clinical features in the orofacial region. Tonic mandibular deviation accompanying ipsilateral downward and lateral lip pulling is the most common phenotype seen in ...
Kazuya Yoshida (8570826)
core   +1 more source

Complex movement disorders in a boy with PURA syndrome

, 2021
[[abstract]]PURA syndrome is a severe neurodevelopmental disorder named after its causative gene, the purine-rich element-binding protein A gene.
Lin, SJ;Lin, YF;Tsai, CH;Huang, CH;Ho, F;Tsai, SF;Lin, WS
core   +1 more source

Functional network reorganization following VIM-MRgFUS for essential tremor

Neurotherapeutics
Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising, noninvasive therapeutic approach for essential tremor (ET), yet the effects of the respective lesions on functional brain network organization remain poorly understood.
Jinlong Liu, Jonas Krauss, Veronika Purrer, Valeri Borger, Markus Essler, Alexander Radbruch, Ullrich Wüllner, Neeraj Upadhyay, Henning Boecker   +8 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Investigation of deep brain stimulation surgery early term results of gait characteristics on Parkinson's disease: Case report

, 2014
Objective: This study was carried out to examine the effect of the Subthalamic nucleus deep brain stimulation (STN-DBS) surgery on the characteristics of the gait.
Ünal, Ayşe, Kavlak, Erdoğan, Pekesen, Mine, Cavlak, Uğur, Çeliker, Özkan, Altuğ, Filiz   +5 more
core  

Video_1_Clinical Characteristics of Functional Movement Disorders in the Stomatognathic System.MP4

, 2020
Background: Functional (psychogenic) movement disorders often have distinguishable clinical features in the orofacial region. Tonic mandibular deviation accompanying ipsilateral downward and lateral lip pulling is the most common phenotype seen in ...
Kazuya Yoshida (8570826)
core   +1 more source

Recognizing Uncommon Presentations of Psychogenic (Functional) Movement Disorders

Tremor and Other Hyperkinetic Movements, 2015
Background: Psychogenic or functional movement disorders (PMDs) pose a challenge in clinical diagnosis. There are several clues, including sudden onset, incongruous symptoms, distractibility, suggestibility, entrainment of symptoms, and lack of response ...
José Fidel Baizabal-Carvallo, Robert Fekete   +1 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Personality disorders and somatization in functional and organic movement disorders

, 2017
Psychiatric disturbances and somatizations are both criteria which support the diagnosis of functional movement disorders. It is unclear, however, whether these factors are helpful in differentiating functional and organic movement disorders.
Margari F., Pellicciari R, Fabio G, Superbo M, Defazio G, Pastore A, Pierri G, Margari F, Gigante AF, PIERRI, Gianpaolo   +9 more
core   +1 more source