Results 101 to 110 of about 6,409,949 (276)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of the Coronavirus Disease 2019 Pandemic on Functional Movement Disorders: Lessons From a Specialized Clinic

Movement Disorders, 2020
The coronavirus disease 2019 (COVID-19) crisis has had a major impact on healthcare systems and patients with movement disorders. Functional movement disorders (FMDs) may affect up to 18% of patients evaluated in movement disorder units and can greatly ...
C. Delgado, I. Pareés, A. Jiménez-Huete, M. Kurtis   +3 more
semanticscholar   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Nosology and Phenomenology of Psychosis in Movement Disorders

, 2020
Background Psychotic symptoms such as delusions and hallucinations are part of the clinical picture of several conditions presenting movement disorders.
Farcy, Nicole, Merello, Marcelo, Starkstein, Sergio E., Rossi, Malco   +3 more
core   +1 more source

Clinical, functional, and quality-of-life characteristics of women with comorbid fibromyalgia and irritable bowel syndrome and their associations with FIQR scores

Frontiers in Physiology
BackgroundFibromyalgia (FM) and irritable bowel syndrome (IBS) frequently co-occur, sharing pathophysiological mechanisms such as central sensitization and gut-brain axis dysregulation. Given that exercise is a first-line non-pharmacological intervention
Antonella Bianco, Nicola Verrelli, Giuseppe Riezzo, Gaetana Laselva, Marco Grasso, Isabella Franco, Laura Prospero, Benedetta D’Attoma, Antonia Ignazzi, Maria Noemy Pastore, Elisa Grazioli, Attilio Parisi, Francesco Russo   +12 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Definition and classification of hyperkinetic movements in childhood [PDF]

, 2010
Hyperkinetic movements are unwanted or excess movements that are frequently seen in children with neurologic disorders. They are an important clinical finding with significant implications for diagnosis and treatment.
Lehman, Rebecca K., Hilla Ben-Pazi, Michaels, Margaret Barry, Gilbert, Donald L., Butler, Erin E., Mark Hallett, Malanga, C. J., Eileen Fowler, Barbara Kornblau, Francisco Valero-Cuevas, Hans Forssberg, Krosschell, Kristin J., Alter, Katharine, MacKinnon, Colum, C. J. Malanga, Rose, Jessica, Mesterman, Ronit, Donald L. Gilbert, Swoboda, Kathy J., Valero-Cuevas, Francisco, Toni S. Pearson, Daofen Chen, Kristin J. Krosschell, Dayanidhi, Sudarshan, Jonathan W. Mink, Kornblau, Barbara, Kathy J. Swoboda, Katharine Alter, Jinnah, H. A., Dagmar Sternad, Sharon L. Gorman, Margaret Barry Michaels, Erin E. Butler, Jessica Rose, Anthony E. Lang, Terence D. Sanger, Mark E. Gormley, Gorman, Sharon L., Sudarshan Dayanidhi, Robert Chen, Lang, Anthony E., Mink, Jonathan W., Darcy L. Fehlings, Forssberg, Hans, Sternad, Dagmar, Barry S. Russman, H. A. Jinnah, Gormley, Mark E., Sanger, Terence D., Colum MacKinnon, Chen, Daofen, Harvey S. Singer, Abigail Collins, Ronit Mesterman, Russman, Barry S., Fowler, Eileen, Pearson, Toni S., Rebecca K. Lehman, Hallett, Mark, Singer, Harvey S., Ben-Pazi, Hilla, Collins, Abigail, Fehlings, Darcy L., Chen, Robert, Fehlings, DL, Hallett, M, Alter, K, Lang, AE, Sanger, TD, Ben-Pazi, H, Butler, EE, Chen, D, Singer, HS, Mink, JW   +73 more
core   +1 more source

Pathogenesis and pathophysiology of functional (psychogenic) movement disorders

Neurobiology of Disease, 2019
Functional movement disorders (FMDs), known over time as “hysteria”, “dissociative”, “conversion”, “somatoform”, “non-organic” and “psychogenic” disorders, are characterized by having a voluntary quality, being modifiable by attention and distraction but
José Fidel Baizabal-Carvallo, Mark Hallett, Joseph Jankovic   +2 more
doaj   +1 more source