Results 81 to 90 of about 6,409,949 (276)

Acute Effects of Subthalamic Deep Brain Stimulation on Motor Outcomes in Parkinson's Disease; 13 Year Follow Up

Frontiers in Neurology, 2019
Objective: Deep brain stimulation of the Subthalamic nucleus (STN-DBS) is a safe and well-established therapy for the management of refractory motor symptoms in Parkinson's disease (PD). Marked improvement in axial symptoms has been reported in the short
Haiyan Zhou, Linbin Wang, Chencheng Zhang, Xian Qiu, Wei Hu, Odin van der Stelt, Adolfo Ramirez-Zamora, Dianyou Li   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Physical capacity modulates intestinal barrier dysfunction in functional disorders: phenotype-specific patterns in fibromyalgia and irritable bowel syndrome

Frontiers in Physiology
BackgroundIntestinal barrier dysfunction is increasingly implicated in the pathophysiology of fibromyalgia (FM) and irritable bowel syndrome (IBS), particularly in their comorbid form. Physical capacity (PC) influences systemic inflammation and metabolic
Francesco Russo, Antonella Bianco, Laura Prospero, Gaetana Laselva, Marco Grasso, Benedetta D’Attoma, Nicola Verrelli, Antonia Ignazzi, Isabella Franco, Francesco Goscilo, Claudia Beatrice Bagnato, Anna Ancona, Maria Notarnicola, Michele Linsalata, Giuseppe Riezzo   +14 more
doaj   +1 more source

An International Survey of Deep Brain Stimulation Utilization in Asia and Oceania: The DBS Think Tank East

Frontiers in Human Neuroscience, 2020
Introduction: To evaluate the current utilization and challenges in fully implementing the use of deep brain stimulation (DBS) treatment in Asia and Oceania.Methods: We conducted a medical literature search to identify DBS research performed by ...
Chencheng Zhang, Adolfo Ramirez-Zamora, Fangang Meng, Zhengyu Lin, Yijie Lai, Dianyou Li, Jinwoo Chang, Takashi Morishita, Tooru Inoue, Shinsuke Fujioka, Genko Oyama, Terry Coyne, Valerie Voon, Paresh K. Doshi, Yiwen Wu, Jun Liu, Bhavana Patel, Leonardo Almeida, Aparna A. Wagle Shukla, Wei Hu, Kelly Foote, Jianguo Zhang, Bomin Sun, Michael S. Okun   +23 more
doaj   +1 more source

Contingent negative variation: a biomarker of abnormal attention in functional movement disorders

European Journal of Neurology, 2020
Contingent negative variation (CNV) is a negative cortical wave that precedes a pre‐cued imperative stimulus requiring a quick motor response. It has been related to motor preparation and anticipatory attention.
Tiago Teodoro, Akihiro Koreki, A. Meppelink, S. Little, G. Nielsen, A. Macerollo, J. Ferreira, I. Pareés, A. Lang, M. Edwards   +9 more
semanticscholar   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Clinical Management of Movement Disorders

Movement disorders represent a heterogeneous field of Neurology that includes a wide variety of diseases. Phenomenologically, such disturbances are classically distinguished into hyperkinetic and hypokinetic disorders.

core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source