Results 161 to 170 of about 1,020,025 (280)

Jointly modelling multiple transplant outcomes by a competing risk model via functional principal component analysis. [PDF]

J Appl Stat, 2023
Dong JJ, Shi H, Wang L, Zhang Y, Cao J.
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Functional data geometric morphometrics with machine learning for craniodental shape classification in shrews

Scientific Reports
This work proposes a functional data analysis approach for morphometrics in classifying three shrew species (S. murinus, C. monticola, and C. malayana) from Peninsular Malaysia.
Aneesha Balachandran Pillay, Dharini Pathmanathan, Sophie Dabo-Niang, Arpah Abu, Hasmahzaiti Omar   +4 more
doaj   +1 more source

Early diagnosis of Alzheimer's disease on ADNI data using novel longitudinal score based on functional principal component analysis. [PDF]

J Med Imaging (Bellingham), 2021
Shi H, Ma D, Nie Y, Faisal Beg M, Pei J, Cao J, Neuroimaging Initiative TAD.   +6 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Multivariate functional principal component analysis identifies waveform features of gait biomechanics related to early-to-moderate hip osteoarthritis. [PDF]

J Orthop Res, 2021
Roach KE, Pedoia V, Lee JJ, Popovic T, Link TM, Majumdar S, Souza RB.   +6 more
europepmc   +1 more source

Generalized functional dynamic principal component analysis

In this paper, we explore dimension reduction for time series of functional data within both stationary and non-stationary frameworks. We introduce a functional framework of generalized dynamic principal component analysis (GDPCA). The concept of GDPCA aims for better adaptation to possible nonstationary features of the series. We define the functional
Khoo, Tzung Hsuen, Dabo, Issa-Mbenard, Pathmanathan, Dharini, Dabo-Niang, Sophie   +3 more
openaire   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Disjoint and Functional Principal Component Analysis for Infected Cases and Deaths Due to COVID-19 in South American Countries with Sensor-Related Data. [PDF]

Sensors (Basel), 2021
Martin-Barreiro C, Ramirez-Figueroa JA, Cabezas X, Leiva V, Galindo-Villardón MP.   +4 more
europepmc   +1 more source