Results 91 to 100 of about 5,666,463 (234)

Functional requirements of a mobile-based application for stroke self-management: A Delphi study. [PDF]

Healthc Technol Lett, 2022
Tadayon H, Masoud SA, Nabovati E, Akbari H, Farzandipour M, Babaei M.   +5 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Identifying Preferred Appearance and Functional Requirements of Aged Care Robots Among Older Chinese Immigrants: Cross-Sectional Study. [PDF]

JMIR Aging, 2023
Chiu CJ, Lo YH, Montayre J, Abu-Odah H, Chen ML, Zhao IY.   +5 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Functional requirements for a Samd14-capping protein complex in stress erythropoiesis. [PDF]

Elife, 2022
Ray S, Chee L, Zhou Y, Schaefer MA, Naldrett MJ, Alvarez S, Woods NT, Hewitt KJ.   +7 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

An Intelligent Model to Predict Functional and Non-Functional Requirements From Software Requirements Specification

IEEE Access
Automated classification of Functional Requirements (FRs) and Non-Functional Requirements (NFRs) is a fundamental task in requirements engineering, yet it remains challenging due to the short length, domain specificity, and severe class imbalance of ...
Martina Girgis Said, Laila M. El-Fangary, Safaa M. Azzam, Amr A. Abohany   +3 more
doaj   +1 more source

iNKT subsets differ in their developmental and functional requirements on Foxo1. [PDF]

Proc Natl Acad Sci U S A, 2021
Zhang H, Zhang Y, Pan J, Wu Q, Huang Y, Bai S, Tian C, Zhu M, Lian Z, Li F, Tian Z, Bai L.   +11 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Functional Requirements for Medical Data Integration into Knowledge Management Environments: Requirements Elicitation Approach Based on Systematic Literature Analysis. [PDF]

J Med Internet Res, 2023
Kinast B, Ulrich H, Bergh B, Schreiweis B.   +3 more
europepmc   +1 more source