Results 91 to 100 of about 2,400,920 (303)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Advanced flight deck/crew station simulator functional requirements [PDF]

This report documents a study of flight deck/crew system research facility requirements for investigating issues involved with developing systems, and procedures for interfacing transport aircraft with air traffic control systems planned for 1985 to 2000.
Moss, M. J., Tate, J. L., Wall, R. L.
core   +1 more source

T-Reqs: Tool Support for Managing Requirements in Large-Scale Agile System Development

, 2018
T-Reqs is a text-based requirements management solution based on the git version control system. It combines useful conventions, templates and helper scripts with powerful existing solutions from the git ecosystem and provides a working solution to ...
Gildert, Pierre, Horkoff, Jennifer, Kasauli, Rashidah, Knauss, Eric, Lange, Filip, Liebel, Grischa, Wohlrab, Rebekka   +6 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Advanced information processing system: Inter-computer communication services [PDF]

The purpose is to document the functional requirements and detailed specifications for the Inter-Computer Communications Services (ICCS) of the Advanced Information Processing System (AIPS).
Alger, Linda S., Burkhardt, Laura, Masotto, Tom, Sims, J. Terry, Whittredge, Roy   +4 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Functional requirements decomposition in set-based design

Design Science
Designing systems is typically uncertain and ambiguous at the early stages. Set-based design (SBD) supports alternative exploration and gradual uncertainty reduction during the early lifecycle, making it practical for complex system design.
Minghui Sun, Zhaoyang Chen, Georgios Bakirtzis, Hassan Jafarzadeh, Cody Fleming   +4 more
doaj   +1 more source

The 30/20 GHz communications system functional requirements [PDF]

The characteristics of 30/20 GHz usage in satellite systems to be used in support of projected communication requirements of the 1990's are defined. A requirements analysis which develops projected market demand for satellite services by general and ...
Frankfort, M., Markham, R., Siperko, C. M., Wall, M.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploring Requirements Engineering for Machine Learning via a Product Case Study

Proceedings of the International Florida Artificial Intelligence Research Society Conference
Requirements Engineering (RE) is a well-defined process in software development. Through customer requirement elicitation techniques, Non-Functional Requirements (NFRs) and the Functional Requirements (FRs) that implement them, are defined.
Lynn Vonderhaar, Timothy Elvira, Juan Couder, Omar Ochoa   +3 more
doaj   +1 more source