Results 41 to 50 of about 667,116 (261)

Renal Function and Bisphosphonate Safety

Journal of Bone and Mineral Research, 2008
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Wheeler, David, Ott, Susan M., Moe, Sharon, McCann, Linda, Wang, Angela Yee Moon, Weisinger, Jose, Elder, Grahame, Jorgetti, Vanda, Fukagawa, Masafumi, Langman, Craig B., Drueke, Tilman   +10 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Elastic Gateway Functional Safety Architecture and Deployment: A Case Study

IEEE Access, 2022
The automotive industry has started its transformation towards Software-Defined Vehicles. This transformation is driven by the rise of the number of vehicle features, the high complexity of these features and their constraining availability requirements ...
Abdoul Aziz Kane, Angela Gonzalez Marino, Francesc Fons, Sandro Nueesch, Piotr Serwa, Michael Schoetz   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Safety Architecture Proposal for Low-Latency Sensor/Actuator Networks using IO-Link Wireless

IEEE Access, 2022
In the field of production automation, IO-Link Wireless (IOLW) offers energy-efficient and cost-effective solutions for networking wireless sensors and actuators close to the machines on the industrial shop-floor. In this paper, a concept is presented to
Thomas R. Doebbert, Christoph Cammin, Gerd Scholl   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evidence of the Effectiveness of Cyclic Technical Safety Mechanisms

IEEE Access, 2021
At the vehicle powernet level, technical safety mechanisms, e.g., smart switching modules, mainly operate in a discrete-time or cyclic manner. In accordance with the functional safety standard ISO 26262, safety-related E/E systems require a safety ...
Armin Kohler, Bernd Bertsche
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Safety assessment of virtualization computing platform for avionics system of civil aircraft

Xibei Gongye Daxue Xuebao
Aiming at the main problems that affect the security of airborne computing platform after virtualization, such as time-space isolation, fault isolation and schedulability, this paper studies the security level evaluation of airborne computing platform ...
YANG Huan, WANG Xiaodong, LI Geng, ZHANG Shuang, GUO Yangming   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source