Results 51 to 60 of about 667,116 (261)

Research on the System Architecture of EV Motor Control Unit Based on Functional Safety

Kongzhi Yu Xinxi Jishu, 2018
This paper presented the basic methods of hazard analysis and risk assessment which based on the functional safety related standards, and then the safety goal and ASIL of EV motor control unit have been derived according to HARA.
WU Lixun, CHEN Jianming, CHEN Lei, ZHENG Hanfeng   +3 more
doaj  

A High-Level Synthesis Library for Synthesizing Efficient and Functional-Safe CNN Dataflow Accelerators

IEEE Access
Convolution neural networks (CNNs) are widely applied in many machine learning applications. Hardware acceleration for CNNs is crucial, given their high computational intensity and the demand for enhanced energy efficiency and reduced latency in ...
Dionysios Filippas, Christodoulos Peltekis, Vasileios Titopoulos, Ioannis Kansizoglou, Georgios CH. Sirakoulis, Antonios Gasteratos, Giorgos Dimitrakopoulos   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Integrating Machinery Safety Functions Into Functional Safety for Process Industry

Chemical Engineering Transactions
From a Process Industry point of view, the integration of Machinery Safety Functions into Functional Safety for Process Safety has always been a challenge. Generally, concepts of IEC 61511 „Functional safety – Safety instrumented systems for the process industry sector” are the basis for safety functions in Process Industry – however these concepts are
Schmitt-Pauksztat Gregor, Hablawetz Dirk, Knoedler Marco, de-Kerf Dominic, Demski Christian, Risser Marc, Dehner Udo   +6 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Functional safety verification and performance measurement of train-train communication link

Journal of Measurement Science and Instrumentation, 2021
The short-range wireless communication technology has advanced considerably and provides the feasibility of traintrain（T2 T）communication link in the communication-based train control system.The introduction of the T2 Tlink would reduce the headway and ...
LIN Junting, XU Qian, CHEN Yong
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Critical Infrastructure Surveillance Using SecureWireless Sensor Networks

Journal of Sensor and Actuator Networks, 2015
In this work, a secure wireless sensor network (WSN) for the surveillance, monitoring and protection of critical infrastructures was developed. To guarantee the security of the system, the main focus was the implementation of a unique security concept ...
Michael Niedermeier, Xiaobing He, Hermann de Meer, Carsten Buschmann, Klaus Hartmann, Benjamin Langmann, Michael Koch, Stefan Fischer, Dennis Pfisterer   +8 more
doaj   +1 more source