Results 131 to 140 of about 562,336 (295)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Functional Selectivity of Dopamine D1 Receptor Signaling: Retrospect and Prospect. [PDF]
Int J Mol Sci, 2021 Yang Y.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Enantioselective semireduction of allenes
Nature Communications, 2017 Reduction of allenes poses several challenges in terms of chemo-, regio- and enantio-selectivity. Here, the authors report a rhodium-Josiphos catalytic system that reduces a variety of aryl allenes to chiral benzylic compounds with excellent selectivity ...
Zhiwei Chen, Vy M. Dong
doaj +1 more source
Functional Selectivity of Coumarin Derivates Acting via GPR55 in Neuroinflammation. [PDF]
Int J Mol Sci, 2022 Apweiler M +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Single-cell selectivity and functional architecture of human lateral occipital complex.
PLoS Biology, 2019 The human lateral occipital complex (LOC) is more strongly activated by images of objects compared to scrambled controls, but detailed information at the neuronal level is currently lacking. We recorded with microelectrode arrays in the LOC of 2 patients
Thomas Decramer +6 more
doaj +1 more source
Bayesian Functional Region Selection
StatABSTRACTLocal regions on curves, images and other high‐dimensional objects often contain critical information for interpretation, prediction and decision‐making. Therefore, detecting local regions on functional data that are relevant to a variable of interest is highly desirable.
Hongxiao Zhu, Yizhi Sun, Jaeyoung Lee
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Development and organization of the retinal orientation selectivity map
Nature CommunicationsOrientation or axial selectivity, the property of neurons in the visual system to respond preferentially to certain angles of visual stimuli, plays a pivotal role in our understanding of visual perception and information processing.
Dominic J. Vita +4 more
doaj +1 more source