Results 111 to 120 of about 562,336 (295)

Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor

Cell Reports, 2019
Summary: Adrenergic G-protein-coupled receptors (GPCRs) mediate different cellular signaling pathways in the presence of endogenous catecholamines and play important roles in both physiological and pathological conditions.
Xiaoyu Chen, Yueming Xu, Lu Qu, Lijie Wu, Gye Won Han, Yu Guo, Yiran Wu, Qingtong Zhou, Qianqian Sun, Cenfeng Chu, Jie Yang, Liu Yang, Quan Wang, Shuguang Yuan, Ling Wang, Tao Hu, Houchao Tao, Yaping Sun, Yunpeng Song, Liaoyuan Hu, Zhi-Jie Liu, Raymond C. Stevens, Suwen Zhao, Dong Wu, Guisheng Zhong   +24 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines.

PLoS ONE, 2019
The last fifteen years have seen the emergence and overflow into the drug scene of "superpotent" N-benzylated phenethylamines belonging to the "NBOMe" series, accompanied by numerous research articles.
Miguel Toro-Sazo, José Brea, María I Loza, Marta Cimadevila, Bruce K Cassels   +4 more
doaj   +1 more source

Learning to Select a Ranking Function [PDF]

, 2010
Learning To Rank (LTR) techniques aim to learn an effective document ranking function by combining several document features. While the function learned may be uniformly applied to all queries, many studies have shown that different ranking functions favour different queries, and the retrieval performance can be significantly enhanced if an appropriate
Jie Peng 0003, Craig Macdonald, Iadh Ounis   +2 more
openaire   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Functional Intimate Association Analysis: A Doctrinal Shift To Save the Roberts Framework [PDF]

, 2012
In Roberts v. U.S. Jaycees, the Supreme Court recognized intimate association as one of the two distinct senses of the freedom of association. In doing so, the Court identified two essential functions that justify constitutional protection for the ...
Roling, Joshua P.
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

To Be Biased or Not to Be: A Play for G-Protein Coupled Receptors

International Journal of Translational Medicine
G protein-coupled receptors (GPCRs) are the largest family of diverse receptors in eukaryotic organisms, playing a critical role in modulating human physiology. It therefore comes as no surprise that about 36% of all currently available drugs target this
Nikitas G. Liolitsas, Evangelia Pantazaka, Evangelia Papadimitriou   +2 more
doaj   +1 more source

Isotherm Studies of Pyrogallol-imprinted Polymers via Precipitation Polymerization

International Journal of Technology, 2017
Molecularly imprinted polymers (MIPs) have been the most convenient and selected methods in detection and extraction for many types of specific targets in various fields.
Nor Amira Othman, Noor Fadilah Yusof, Rusli Daik, Faizatul Shimal Mehamod   +3 more
doaj   +1 more source