Results 91 to 100 of about 562,336 (295)
Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity. [PDF]
PLoS ONE, 2015 Functional selectivity (or biased agonism) is a property exhibited by some G protein-coupled receptor (GPCR) ligands, which results in the modulation of a subset of a receptor's signaling capabilities and more precise control over complex biological ...
Sean M Peterson +2 more
doaj +1 more source
, 2015 The mechanism of the selective dispersion of single-walled carbon nanotubes (CNTs) by polyfluorene polymers is studied in this paper. Using extensive molecular dynamics simulations, it is demonstrated that diameter selectivity is the result of a ...
Arianna Filoramo +6 more
core +5 more sources
The role of selection in functional explanations [PDF]
Manuscrito, 2014 In this essay I will argue that natural selection is more important to functional explanations than what has been thought in some of the literature in philosophy of biology. I start by giving a brief overview of the two paradigms cases of functional explanations: etiological functions and causal-role functions. i then consider one particular attempt to
openaire +4 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Frontiers in Molecular BiosciencesIntroductionG protein-coupled receptors (GPCRs) are the most widely targeted class of signaling proteins, comprising ∼30% of FDA-approved drugs.
Braden S. Fallon +2 more
doaj +1 more source
Z-Selectivity in Olefin Metathesis with Chelated Ru Catalysts: Computational Studies of Mechanism and Selectivity [PDF]
, 2012 The mechanism and origins of Z-selectivity in olefin metathesis with chelated Ru catalysts were explored using density functional theory. The olefin approaches from the “side” position of the chelated Ru catalysts, in contrast to reactions with previous ...
Dong, Xiaofei +6 more
core +1 more source
Tipping the balance: theoretical interrogation of divergent extended heterolytic fragmentations. [PDF]
, 2020 Herein we interrogate a type of heterolytic fragmentation reaction called a 'divergent fragmentation' using density functional theory (DFT), natural bond orbital (NBO) analysis, ab initio molecular dynamics (AIMD), and external electric field (EEF ...
Laconsay, Croix J +2 more
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Influence of Pyrolysis Parameters on the Performance of CMSM [PDF]
, 2009 Carbon hollow fiber membranes have been prepared by pyrolysis of a P84/S-PEEK blend. Proximate analysis of the precursor was performed using thermogravimetry (TGA), and a carbon yield of approximately 40% can be obtained.
Campo, Marta C. +5 more
core +7 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Continuity in the neural system supporting children's theory of mind development: Longitudinal links between task-independent EEG and task-dependent fMRI. [PDF]
, 2019 Children's explicit theory of mind (ToM) understandings change over early childhood. We examined whether there is longitudinal stability in the neurobiological bases of ToM across this time period. A previous study found that source-localized resting EEG
Bowman, Lindsay C +3 more
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