Results 81 to 90 of about 562,336 (295)

Polyoxometalate-intercalated layered double hydroxides as efficient and recyclable bi-functional catalysts for cascade reactions [PDF]

, 2016
The polyoxometalate (POM) intercalated-layered double hydroxides (LDHs) have been widely used as heterogeneous catalysts. However, the application of POM-LDHs as bi-functional catalysts for cascade reaction has seldom been studied comparing with the ...
Angelescu, Aronson, Chen, Chen, Chen, Climent, Corma, Dou, Farsani, Felpin, Finke, Fogg, Han, Iyi, Jiang, Kuroda, Kuwahara, Li, Liu, Liu, Liu, Mallik, Miras, Nakagawa, Neumann, Ramachary, Salvati, Taarning, Toma, Toyao, Wang, Wasilke, Xu, Yang, Yang, Yin, Yonehara, Zhang, Zhao, Zhao, Zhao, Zhu   +41 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1 : contributions of the pore domains [PDF]

, 2007
We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1.
A Sali, AD O’Connell, AJ Patel, C Girard, C Karschin, CMB Lopes, CMB Lopes, D Bichet, D Bockenhauer, D Kim, D Kim, D Leonoudakis, DA Bayliss, DA Doyle, DL Prole, F Bezanilla, F Duprat, F Lesage, F Lesage, F Maingret, G Czirják, G Czirják, G Yellen, I Ashmole, I Lauritzen, I So, I. Ashmole, J Lopez-Barneo, JF Cordero-Morales, JF Cordero-Morales, JG Starkus, K. H. Yuill, KH Yuill, KJ Buckler, L Heginbotham, L Pei, LJ McGuffin, M Taglialatela, M. J. Sutcliffe, MJ Morton, ML Chapman, N Decher, N Zilberberg, P Hadjú, P. J. Stansfeld, P. R. Stanfield, PR Stanfield, R MacKinnon, R Reyes, S Rajan, S Somodi, SA Goldstein, SC Tosatto, SJ Kehl, TJ Jentsch, TW Claydon, X Li, Y Kim, Y Zhou, ZA Wood   +59 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

On the functional window of the avian compass

, 2017
The functional window is an experimentally observed property of the avian compass that refers to its selectivity around the geomagnetic field strength.
Ganguly, Swaroop, Kondabagil, Kiran, Poonia, Vishvendra Singh, Saha, Dipankar   +3 more
core   +1 more source

Deciphering the brain's codes [PDF]

, 1991
The two sensory systems discussed use similar algorithms for the synthesis of the neuronal selectivity for the stimulus that releases a particular behavior, although the neural circuits, the brain sites involved, and even the species are different.
Konishi, Masakazu
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Preliminary specifications for the sex- and area-specific Operating Models for testing OMPs for the South Coast rock lobster resource [PDF]

, 2016
Johnston and Butterworth (2008b) presented some initial results for sex- and areaspecific age structured production models intended to serve as operating models for testing OMPs for the south coast rock lobster resource.
Johnston, Susan J, Butterworth, Doug S
core  

Inelastic scattering and local heating in atomic gold wires [PDF]

, 2004
We present a method for including inelastic scattering in a first-principles density-functional computational scheme for molecular electronics. As an application, we study two geometries of four-atom gold wires corresponding to two different values of ...
Antti-Pekka Jauho, H. Haug, Mads Brandbyge, Nicolás Lorente, Thomas Frederiksen   +4 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source