Results 61 to 70 of about 562,336 (295)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Glomerular perm-selective function

Kidney International, 1994
The glomerular capillary wall functions as an efficient barrier that restricts the passage of plasma proteins and allows a high flow rate of filtration for plasma water and small solutes. Experimental studies have confirmed the theoretical predictions that circulating macromolecules are retained within the lumen of glomerular capillaries because of ...
Remuzzi, Andrea, Remuzzi, Giuseppe
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Dynamic reorganization of the middle fusiform gyrus: long-term bird expertise predicts decreased face selectivity [PDF]

, 2008
What is the functional relationship between face-selective and expertise-predicated object-selective regions in the human middle fusiform gyrus? In two separate fMRI experiments, superior behaviorally-measured bird expertise predicts both higher middle ...
Chun-Chia Kung, Colin Ellis, Michael J. Tarr   +2 more
core   +1 more source

Selecting the derivative of a functional covariate in scalar-on-function regression

Statistics and Computing, 2022
This paper presents tests to formally choose between regression models using different derivatives of a functional covariate in scalar-on-function regression. We demonstrate that for linear regression, models using different derivatives can be nested within a model that includes point-impact effects at the end-points of the observed functions ...
Giles Hooker, Han Lin Shang
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Utilization of Biased G Protein-Coupled Receptor Signaling towards Development of Safer and Personalized Therapeutics

Molecules, 2019
G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family.
Metehan Ilter, Samman Mansoor, Ozge Sensoy   +2 more
doaj   +1 more source

Region of interest selection for functional features

Neurocomputing, 2021
Feature selection is a critical component in supervised learning to improve model performance. Searching for the optimal feature candidates can be NP-hard. With limited data, cross-validation is widely used to alleviate overfitting, which unfortunately suffers from high computational cost. We propose a highly innovative strategy in feature selection to
Qiyue Wang, Yao Lu 0026, Xiaoke Zhang, James K. Hahn   +3 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structure–function relationship of dynorphin B variants using naturally occurring amino acid substitutions

Frontiers in Pharmacology
Dynorphins (Dyn) represent the subset of endogenous opioid peptides with the highest binding affinity to kappa opioid receptors (KOPrs). Activation of the G-protein-coupled pathway of KOPrs has strong anticonvulsant effects.
Luca Zangrandi, Luca Zangrandi, Barbara Fogli, Anna Mutti, René Staritzbichler, Victoria Most, Peter W. Hildebrand, Peter W. Hildebrand, Regine Heilbronn, Christoph Schwarzer   +9 more
doaj   +1 more source