Results 41 to 50 of about 562,336 (295)

Personalized Medicine in Malignant Melanoma: Towards Patient Tailored Treatment

Frontiers in Oncology, 2018
Despite enormous international efforts, skin melanoma is still a major clinical challenge. Melanoma takes a top place among the most common cancer types and it has one of the most rapidly increasing incidences in many countries around the world.
Hildur Helgadottir, Hildur Helgadottir, Iara Rocha Trocoli Drakensjö, Iara Rocha Trocoli Drakensjö, Ada Girnita, Ada Girnita   +5 more
doaj   +1 more source

Dynamics of Site Selectivity in Dissociative Electron Attachment in Aromatic Molecules

Atoms, 2022
Dissociative electron attachment has shown site selectivity in aliphatic molecules based on the functional groups present in them. This selectivity arises from the core excited resonances that have excited parent states localized to a specific site of ...
Vishvesh Tadsare, Sukanta Das, Samata Gokhale, E. Krishnakumar, Vaibhav S. S. Prabhudesai   +4 more
doaj   +1 more source

The functional organization of area V2, I: Specialization across stripes and layers [PDF]

, 2002
We used qualitative tests to assess the sensitivity of 1043 V2 neurons (predominantly multiunits) in anesthetised macaque monkeys to direction, length. orientation. and color of moving bar stimuli.
Shipp, S, Zeki, S
core   +1 more source

Selective N‐Deacetylation and Functionalization of Aminosugars [PDF]

European Journal of Organic Chemistry, 2022
AbstractN‐Acetyl groups are abundant functional groups found in a variety of biomolecules including aminosugars. N‐Acetyl groups are chemically stable and harsh conditions are often needed to remove them. Herein, we report a mild and efficient protocol to remove N‐acetyl groups in the presence of esters and carbamates and functionalize the resulting ...
Sam J. Moons, Alexander D. Robertson, Thomas J. Boltje   +2 more
openaire   +2 more sources

AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems

Entropy, 2015
In performing their biological functions, molecular machines must process and transmit information with high fidelity. Information transmission requires dynamic coupling between the conformations of discrete structural components within the protein ...
Michael V. LeVine, Harel Weinstein
doaj   +1 more source

In Vitro Selection of Functional Lantipeptides

Journal of the American Chemical Society, 2012
In this report we present a method to identify functional artificial lantipeptides. In vitro translation coupled with an enzyme-free protocol for posttranslational modification allows preparation of more than 10(11) different lanthionine containing peptides. This diversity can be searched for functional molecules using mRNA-lantipeptide display.
Hofmann, Frank, Szostak, Jack W., Seebeck, Florian P.   +2 more
openaire   +5 more sources

Functional Selectivity in GPCR Heterocomplexes [PDF]

Mini-Reviews in Medicinal Chemistry, 2012
G protein-coupled receptors (GPCRs) can couple to more than one signaling pathway. Biophysical studies and pharmacological theory indicate that they exist in different active conformations that differ in their capacity to activate specific signaling pathways.
J, González-Maeso, S C, Sealfon
openaire   +2 more sources

Promoting H2O2 production via 2-electron oxygen reduction by coordinating partially oxidized Pd with defect carbon. [PDF]

, 2020
Electrochemical synthesis of H2O2 through a selective two-electron (2e-) oxygen reduction reaction (ORR) is an attractive alternative to the industrial anthraquinone oxidation method, as it allows decentralized H2O2 production. Herein, we report that the
Chang, Qiaowan, Chen, Jingguang G, Chen, Zheng, Denny, Steven R, Gao, Hongpeng, Lee, Ji Hoon, Mostaghimi, Amir Hassan Bagherzadeh, Siahrostami, Samira, Xin, Huolin L, Zhang, Pu, Zhang, Ying, Zhao, Xueru   +11 more
core  

The Influence of Carboxyl-Functionalized Carbon Dots on Ethanol Selectivity in Gas Sensing

Chemosensors, 2023
For semiconductor tin dioxide (SnO2) materials, the oxygen adsorption theory often struggles to explain their selectivity towards specific gases. Therefore, it is worth considering altering the surface functional groups of SnO2 to modify its surface ...
Futong Tian, Guoxing Ma, Xing Zhao, Jie Gao, Jingwen Zhang, Hui Suo, Chun Zhao   +6 more
doaj   +1 more source

Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation

Nature Communications, 2021
Low-intensity transcranial focused ultrasound (tFUS) is a non-invasive neuromodulation technique with high spatial specificity. The authors show that excitatory and inhibitory neurons respond differently to tFUS, suggesting the possibility of ...
Kai Yu, Xiaodan Niu, Esther Krook-Magnuson, Bin He   +3 more
doaj   +1 more source