Results 31 to 40 of about 562,336 (295)

Selective functionalization of a bis-silylene [PDF]

Chemical Communications, 2013
Functionalization of N-heterocyclic carbenes (NHCs) has an important influence on their stability, Lewis donor, and acceptor properties. In this study, we report on the selective functionalization of a four-membered N-heterocyclic bis-silylene (2,6-Ar2C6H3NSi:)2 (1) (Ar = 2,4,6-iPr3C6H2) with mono-oxygen sources N2O and Me3NO.
Ghadwal, Rajendra, Azhakar, Ramachandran, Pröpper, Kevin, Dittrich, Birger, John, Michael   +4 more
openaire   +4 more sources

BIASED AGONISM OF THREE DIFFERENT CANNABINOID RECEPTOR AGONISTS IN MOUSE BRAIN CORTEX

Frontiers in Pharmacology, 2016
Cannabinoid receptors are able to couple to different families of G-proteins when activated by an agonist drug. It has been suggested that different intracellular responses may be activated depending on the ligand.
Rebeca Diez-Alarcia, Rebeca Diez-Alarcia, Inés Ibarra-Lecue, Ángela Patricia López-Cardona, Ángela Patricia López-Cardona, Javier Meana, Javier Meana, Alfonso Gutierrez-Adán, Luis F Callado, Luis F Callado, Ekaitz Agirregoitia, Leyre Urigüen, Leyre Urigüen   +12 more
doaj   +1 more source

Allosteric and biased G protein-coupled receptor signaling regulation: Potentials for new therapeutics

Frontiers in Endocrinology, 2014
G protein-coupled receptors (GPCRs) are seven plasma membrane (PM)-spanning proteins that participate in many aspects of the endocrine function and are important targets for drug development. They transduce signals mainly, but not exclusively, via hetero-
Etienne eKhoury, Stéphanie eClément, Stéphane Alain Laporte   +2 more
doaj   +1 more source

Adenosine A_2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease

Cells, 2020
(1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR), which is one of the main targets to combat Alzheimer’s disease (AD), is expressed in both neurons and glial cells.
Rafael Franco, Rafael Rivas-Santisteban, Mireia Casanovas, Alejandro Lillo, Carlos A. Saura, Gemma Navarro   +5 more
doaj   +1 more source

Agonist-Biased Signaling via Matrix Metalloproteinase-9 Promotes Extracellular Matrix Remodeling

Cells, 2018
The extracellular matrix (ECM) is a highly dynamic noncellular structure that is crucial for maintaining tissue architecture and homeostasis. The dynamic nature of the ECM undergoes constant remodeling in response to stressors, tissue needs, and ...
Bessi Qorri, Regina-Veronicka Kalaydina, Aleksandra Velickovic, Yekatrina Kaplya, Alexandria Decarlo, Myron R. Szewczuk   +5 more
doaj   +1 more source

Amine catalysis for the organocatalytic diboration of challenging alkenes [PDF]

, 2016
© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The generation of in situ sp 2 –sp 3 diboron adducts has revolutionised the synthesis of organoboranes.
Althaus, Blaisdell, Bonet, Bonet, Bonet, Burns, Cade, Cid, Cid, Clegg, Cuenca, Dewhurst, Dutheuil, Fang, Gao, Gao, Kleeberg, Kojima, Lee, Lee, Miralles, Miralles, Mkhalid, Neeve, Nguyen, Pietsch, Pubill-Ulldemolins, Sanz, Schmidt, Stymiest, Thorpe, Watson, Yanga, Yoshimura, Zhang, Zheng   +35 more
core   +1 more source

Coordinated optimization of visual cortical maps (II) Numerical studies [PDF]

, 2012
It is an attractive hypothesis that the spatial structure of visual cortical architecture can be explained by the coordinated optimization of multiple visual cortical maps representing orientation preference (OP), ocular dominance (OD), spatial frequency,
A Antonini, A Das, A Grabska-Barwinska, A Grinwald, A Jacobs, A Shmuel, A Soward, A Zepeda, AA Koulakov, AP Bartsch, B Chapman, BA Malomed, BJ Farley, BS Wang, C Blakemore, C Blakemore, C von der Malsburg, CE Giacomantonio, CF Stevens, CJ Shatz, CJ Shatz, CN Levelt, D Bensimon, D Boyer, D Boyer, D Mitchell, D Shulz, DC Johns, DE Mitchell, DE Mitchell, DE Mitchell, DL Adams, DL Adams, DL Ringach, DL Ringach, Dominik Heide, E Bartfeld, E Bodenschatz, E Erwin, E Erwin, EM Slimko, F Wolf, F Wolf, F Wolf, FH Busse, Fred Wolf, GG Blasdel, GG Blasdel, GG Blasdel, GJ Goodhill, H Nakagama, H Ritter, H Wassle, H Yu, HY Lee, HZ Shouval, JA Bednar, JA Bednar, JB Swift, JE Dennis, JR Villablanca, Justin C. Crowley, K Albus, K Lehmann, K Obermayer, K Obermayer, K Obermayer, K Ohki, KD Miller, KD Miller, KD Miller, KR Duffy, KR Jones, L Reichl, L Reichl, Lars Reichl, LE White, LE White, M Argentina, M Cynader, M Hammele, M Hübener, M Imbert, M Kaschube, M Kaschube, M Kaschube, M Kaschube, M Kaschube, M Sato, M Schnabel, M Weliky, MA Carreira-Perpinan, Matthias Kaschube, MC Crair, MC Cross, MW Cho, MW Cho, N Mayer, ND Mermin, NL Rochefort, NP Issa, NV Swindale, NV Swindale, NV Swindale, NV Swindale, NV Swindale, NV Swindale, NW Daw, Olaf Sporns, P Buisseret, P Buisseret, P Coullet, PC Bressloff, PN Brown, R Engelmann, RAW Galuske, RE Soodak, S Grossberg, S LeVay, S Löwel, S Löwel, S Löwel, S Rathjen, S Rathjen, S Schuett, SB Paik, SC Rao, Siegrid Löwel, SJ Espinosa, T Bonhoeffer, T Bonhoeffer, T Bonhoeffer, TN Wiesel, U Ernst, W Keil, W Keil, W Zhang, W Zimmermann, W Zimmermann, WH Bosking, X Xu, Y Diao, Y Fregnac, Y Fregnac, Y Fregnac, Y Kremer, Y Li, Y Li, Y Pomeau, Y Pomeau   +149 more
core   +8 more sources

Allosteric modulation of chemoattractant receptors

Frontiers in Immunology, 2016
Chemoattractants control selective leukocyte homing via interactions with a dedicated family of related GPCR. Emerging evidence indicates that the signalling activity of these receptors, as for other GPCR, is influenced by allosteric modulators, which ...
Maria Candida Cesta, Marcello eAllegretti, Massimo eLocati, Massimo eLocati   +3 more
doaj   +1 more source

Binding mode analyses of NAP derivatives as mu opioid receptor selective ligands through docking studies and molecular dynamics simulation [PDF]

, 2017
Mu opioid receptor selective antagonists are highly desirable because of their utility as pharmacological probes for receptor characterization and functional studies.
Wang, Huiqun, Zaidi, Saheem A., Zhang, Yan   +2 more
core   +2 more sources

Cooperative catalysis by silica-supported organic functional groups [PDF]

, 2008
Hybrid inorganic–organic materials comprising organic functional groups tethered from silica surfaces are versatile, heterogeneous catalysts. Recent advances have led to the preparation of silica materials containing multiple, different functional groups
Davis, Mark E., Margelefsky, Eric L., Zeidan, Ryan K.   +2 more
core   +1 more source