Results 21 to 30 of about 562,336 (295)
Frontiers in Synaptic Neuroscience, 2018 The dopamine D2 receptor (D2R) is known to elicit effects through activating two major signaling pathways mediated by either G proteins (Gi/o) or β-arrestins.
Lani S. Chun +12 more
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Z-Selective Homodimerization of Terminal Olefins with a Ruthenium Metathesis Catalyst [PDF]
, 2011 The cross-metathesis of terminal olefins using a novel ruthenium catalyst results in excellent selectivity for the Z-olefin homodimer. The reaction was found to tolerate a large number of functional groups, solvents, and temperatures while maintaining ...
Endo, Koji +3 more
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Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor
Biomolecules, 2021 The dopamine D2/D3 receptor (D2R/D3R) agonists are used as therapeutics for Parkinson’s disease (PD) and other motor disorders. Selective targeting of D3R over D2R is attractive because of D3R’s restricted tissue distribution with potentially fewer side ...
Pramisha Adhikari +7 more
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How cinchona alkaloid-derived primary amines control asymmetric electrophilic fluorination of cyclic ketones. [PDF]
, 2014 The origin of selectivity in the α-fluorination of cyclic ketones catalyzed by cinchona alkaloid-derived primary amines is determined with density functional calculations.
Houk, KN, Lam, Yu-hong
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Functional Organization of Visual Cortex in the Owl Monkey [PDF]
, 2004 In this study, we compared the organization of orientation preference in visual areas V1, V2, and V3. Within these visual areas, we also quantified the relationship between orientation preference and cytochrome oxidase (CO) staining patterns. V1 maps of
Bosking, W. +5 more
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Selection games on continuous functions [PDF]
Topology and its Applications, 2020 In this paper we study the selection principle of closed discrete selection, first researched by Tkachuk in [13] and strengthened by Clontz, Holshouser in [3], in set-open topologies on the space of continuous real-valued functions. Adapting the techniques involving point-picking games on \(X\) and \(C_p(X)\), the current authors showed similar ...
Caruvana, Christopher, Holshouser, Jared
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Selectivity in binary fluid mixtures: static and dynamical properties [PDF]
, 2009 Selectivity of particles in a region of space can be achieved by applying external potentials to influence the particles in that region. We investigate static and dynamical properties of size selectivity in binary fluid mixtures of two particles sizes ...
Archer, Andrew J. +2 more
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Iridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand. [PDF]
, 2020 The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities
Hartwig, John F +3 more
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Molecules, 2021 Central among the tools and approaches used for ligand discovery and design are Molecular Dynamics (MD) simulations, which follow the dynamic changes in molecular structure in response to the environmental condition, interactions with other proteins, and
Ambrose Plante, Harel Weinstein
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Feature selection for functional data
Journal of Multivariate Analysis, 2016 22 pages, 4 ...
Ricardo Fraiman +2 more
openaire +4 more sources