Results 11 to 20 of about 562,336 (295)
Frontiers in Pharmacology, 2022 The sweet taste receptor is rather unique, recognizing a diverse repertoire of natural or synthetic ligands, with a surprisingly large structural diversity, and with potencies stretching over more than six orders of magnitude.
Nicole B. Servant +9 more
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The Impact of the Secondary Binding Pocket on the Pharmacology of Class A GPCRs
Frontiers in Pharmacology, 2022 G-protein coupled receptors (GPCRs) are considered important therapeutic targets due to their pathophysiological significance and pharmacological relevance. Class A receptors represent the largest group of GPCRs that gives the highest number of validated
Attila Egyed +2 more
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CB1 Cannabinoid Receptor Signaling and Biased Signaling
Molecules, 2021 The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration.
Luciana M. Leo, Mary E. Abood
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Frontiers in Pharmacology, 2022 The classical terms agonists and antagonists for G protein coupled receptors (GPCRs) have often become misleading. Even the biased agonism concept does not describe all the possibilities already demonstrated for GPCRs. The cannabinoid CB2 receptor (CB2R)
Rafael Franco +8 more
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Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides
Biomedicines, 2021 Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and lead ...
Andreas Lieb +6 more
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Self-Selection Consistent Functions [PDF]
Journal of Economic Theory, 2002 This paper studies collective choice rules whose outcomes consist of a collection of simultaneous decisions, each one of which is the only concern of some group of individuals in society. The need for such rules arises in different contexts, including the establishment of jurisdictions, the location of multiple public facilities, or the election of ...
Salvador Barberà, Carmen Beviá
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Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation [PDF]
Cell, 2017 Ah Ram Kim +2 more
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Cells, 2023 Alcohol abuse is a leading risk factor for the public health burden worldwide. Approved pharmacotherapies have demonstrated limited effectiveness over the last few decades in treating alcohol use disorders (AUD).
Kevin Domanegg +2 more
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Frontiers in Neuroscience, 2021 Pyrazoloquinolinones (PQs) are a versatile class of GABAA receptor ligands. It has been demonstrated that high functional selectivity for certain receptor subtypes can be obtained by specific substitution patterns, but so far, no clear SAR rules emerge ...
Jure Fabjan +3 more
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Atomically dispersed Pt-N-4 sites as efficient and selective electrocatalysts for the chlorine evolution reaction [PDF]
, 2020 Chlorine evolution reaction (CER) is a critical anode reaction in chlor-alkali electrolysis. Although precious metal-based mixed metal oxides (MMOs) have been widely used as CER catalysts, they suffer from the concomitant generation of oxygen during the ...
A Kumar +63 more
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