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Novel retinoids with receptor selectivity and functional selectivity
British Journal of Dermatology, 1999Retinoids mediate a number of physiological pathways through their effects on cellular growth and differentiation. Upon binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), retinoids regulate cellular processes by directly modulating the expression of responsive genes.
A, Johnson, R A, Chandraratna
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The American Mathematical Monthly, 2019
When we take a decimal form of a number in the unit interval [0,1], we can form a new number by selecting certain digits and discarding the others.
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When we take a decimal form of a number in the unit interval [0,1], we can form a new number by selecting certain digits and discarding the others.
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Functional Selectivity in Cannabinoid Signaling
Current Molecular Pharmacology, 2008Cannabinoid (CB) agonists exhibit numerous potentially useful pharmacological properties, but unwanted side effects limit their use in clinical practice. Thus, novel strategies are needed to identify potential CB pharmaceuticals with fewer side effects. Activated CB receptors initiate multiple parallel intracellular signal transduction cascades. In the
E V, Varga +7 more
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Estimation and Model Selection for Nonparametric Function-on-Function Regression
Journal of Computational and Graphical Statistics, 2022Regression models with a functional response and functional covariate have received significant attention recently. While various nonparametric and semiparametric models have been developed, there is an urgent need for model selection and diagnostic methods.
Zhanfeng Wang +3 more
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Selective Functionalization of Arbitrary Nanowires
Nano Letters, 2006We report the selective functionalization of uniform and heterostructured nanowires with self-assembled monolayers (SAMs) of (3-mercaptopropyl)trimethoxysilane (MPTMS). The wires were grown electrochemically in anodic aluminum oxide (AAO) templates.
Kwan, Skinner +2 more
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Fixed-point Selection Functions
Lobachevskii Journal of Mathematics, 2021zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Function, selection, and construction in the brain
Synthese, 2012A common misunderstanding of the selected effects theory of function is that natural selection operating over an evolutionary time scale is the only function-bestowing process in the natural world. This construal of the selected effects theory conflicts with the existence and ubiquity of neurobiological functions that are evolutionary novel, such as ...
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Training a selection function for extraction
Proceedings of the eighth international conference on Information and knowledge management, 1999In this paper we compare performance of several heuristics in generating informative generic/query-oriented extracts for newspaper articles in order to learn how topic prominence affects the performance of each heuristic. We study how different query types can affect the performance of each heuristic and discuss the possibility of using machine ...
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Selective Functionalization of Tailored Nanostructures
ACS Nano, 2012The controlled positioning of nanostructures with active molecular components is of importance throughout nanoscience and nanotechnology. We present a novel three-step method to produce nanostructures that are selectively decorated with functional molecules.
Slingenbergh, Winand +7 more
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2016
This chapter focuses on the selected effects theory of function. According to this view, a function of a trait is whatever it was selected for by natural selection or some natural process of selection. I show how the theory plausibly accounts for the explanatory and normative aspects of function.
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This chapter focuses on the selected effects theory of function. According to this view, a function of a trait is whatever it was selected for by natural selection or some natural process of selection. I show how the theory plausibly accounts for the explanatory and normative aspects of function.
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