Results 121 to 130 of about 399,556 (306)
Plesippus francescana (Frick) from the late Pliocene, Coso Mountains, California, with a review of the genus Plesippus [PDF]
, 1936 Two mammalian types, occurring in a late Pliocene fauna from the Coso Mountains, California, have already been described. Among the more abundant forms in this assemblage are the horses of the genus Plesippus.
Schultz, John R.
core
Masticatory Function and Life Style in Aged.
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1998 Elderly people gain enjoyment in their remaining years from eating, speaking and tasting things, and they find that the oral function is necessary to arouse in them a desire to work for society, in addition to looking after their own health, they find that over function is important.
openaire +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Improving Land Cover Classification Accuracy in Satellite Imagery Using Artistic Styles
Applied SciencesThis study addresses ambiguity in spatial extent and boundaries in satellite image classification to improve the accuracy of fine-grained object-based Level 2 land cover classification.
Taeyeon Won, Yang Dam Eo
doaj +1 more source
Data-Driven Shape Analysis and Processing [PDF]
, 2015 Data-driven methods play an increasingly important role in discovering geometric, structural, and semantic relationships between 3D shapes in collections, and applying this analysis to support intelligent modeling, editing, and visualization of geometric
Huang, Qixing +3 more
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Social SciencesIn public security policing, where pressure is constant, effective decision-making and emotion regulation are critical, especially for leaders. These processes significantly impact upon work results, performance, officials’ health, employee well-being ...
Carla Carvalho +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source