Results 71 to 80 of about 895,628 (355)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Functional diversity and functional traits of periphytic algae during a short-term successional process in a Neotropical floodplain lake

Brazilian Journal of Biology
Due to the lack of knowledge in periphytic algae functional diversity patterns during successional processes in floodplains, the present study aimed to analyze the dynamics of the functional traits and functional diversity of periphytic species during a ...
B Dunck, L Rodrigues, DC Bicudo
doaj   +1 more source

Variation in leaf morphological, stomatal, and anatomical traits and their relationships in temperate and subtropical forests

Scientific Reports, 2019
Leaf functional traits have attracted the attention of ecologists for several decades, but few studies have systematically assessed leaf morphological traits (termed “economic traits”), stomatal (termed “hydraulic”), and anatomical traits of entire ...
Congcong Liu, Ying Li, Li Xu, Zhi Chen, Nianpeng He   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Seedling age of Abies georgei var. smithii reveals functional trait coordination in high-altitude habitats in southeast tibet

Frontiers in Ecology and Evolution, 2022
Functional trait-based plant ecology is often used to study plant survival strategies and growth processes. In this work, the variation regularity of functional traits and their correlations were studied in Abies georgei var.
Xinsheng Zhang, Xinsheng Zhang, Xinsheng Zhang, Xinsheng Zhang, Ningning Zhao, Chenni Zhou, Chenni Zhou, Chenni Zhou, Chenni Zhou, Jie Lu, Jie Lu, Jie Lu, Jie Lu, Xiangtao Wang   +13 more
doaj   +1 more source

How can a multimodal approach to primate communication help us understand the evolution of communication? [PDF]

, 2013
Scientists studying the communication of non-human animals are often aiming to better understand the evolution of human communication, including human language.
Burrows, A., Liebal, Katja, Slocombe, K., Waller, Bridget   +3 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Transgressivity in Key Functional Traits Rather Than Phenotypic Plasticity Promotes Stress Tolerance in A Hybrid Cordgrass [PDF]

, 2019
Hybridization might promote offspring fitness via a greater tolerance to environmental stressors due to heterosis and higher levels of phenotypic plasticity.
Castillo Segura, Jesús Manuel, Drenovsky, Rebecca E., Gallego Tévar, Blanca, Grewell, Brenda J.   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Responses of functional traits in cavity-nesting birds to logging in subtropical and temperate forests of the Americas

Scientific Reports, 2021
Logging causes changes in habitat structure, which can potentially lead to variations in taxonomic and functional richness of biodiversity. Studies on how functional traits in birds are affected by logging operations can provide an important element for ...
Alejandro A. Schaaf, Daniela Gomez, Ever Tallei, Constanza G. Vivanco, Román A. Ruggera   +4 more
doaj   +1 more source