Results 121 to 130 of about 6,527,060 (344)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Metabolic Pathways Involved in Regulatory T Cell Functionality
Frontiers in Immunology, 2019 Regulatory T cells (Treg) are well-known for their immune regulatory potential and are essential for maintaining immune homeostasis. The rationale of Treg-based immunotherapy for treating autoimmunity and transplant rejection is to tip the immune balance
Rosalie W M Kempkes +3 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Quantifying human sweetness perception via a TAS1R2/TAS1R3-based model-predicted sweetness score
Food Chemistry: XArtificial sweeteners provide high-intensity sweetness with minimal caloric load, but their evaluation still relies heavily on subjective sensory panels. Psychophysical studies have reported parameters such as sweetness potency, perception threshold, and
Ajung Kim +4 more
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
BMC BiologyBackground The gut microbiome is crucial for human health maintenance and disease development, yet limited understanding of its structure and maintenance hinders effective microbiome-based health improvement strategies.
Seungpyo Hong +4 more
doaj +1 more source
Toward a More Coherent Doctrine of Trademark Genericism and Functionality: Focusing on Fair Competition [PDF]
, 2017 The doctrines of trademark genericism and functionality serve similar functions under the Lanham Act and the common law of unfair competition. Genericism, in the context of word marks, and functionality, for trade dress, bar trademark registration under ...
Rierson, Sandra L.
core +1 more source
Simultaneous spin-based Boolean logic operations with re-programmable functionality
, 2018 Construction of parallel logic gates at nano-scale level undoubtedly improves the efficiency of computable operations. In this work we put forward a new idea of designing two distinct logical operations {\em simultaneously} in the two output leads of a ...
Maiti, Santanu K., Patra, Moumita
core +1 more source
Gap Functions and Lyapunov Functions
Journal of Global Optimization, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
PAPPALARDO, MASSIMO +1 more
openaire +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source