Results 111 to 120 of about 120,410 (255)

A micropolar model for elastic properties in functionally graded materials

Advances in Mechanical Engineering, 2018
By considering the description of phase volume fractions, a micromechanics model is presented for predicting the elastic mechanical properties of isotropic two-phase functionally graded materials. The particle size dependence of the overall elasticity of
Shengyao Fan, Zhanqi Cheng
doaj   +1 more source

Microstructure-based modeling of elastic functionally graded materials: One dimensional case

, 2008
Functionally graded materials (FGMs) are two-phase composites with continuously changing microstructure adapted to performance requirements. Traditionally, the overall behavior of FGMs has been determined using local averaging techniques or a given ...
Beran, Ching, Duddeck, Jan Zeman, Milton, Murat, Neubrand, Rektorys, Zahra Sharif-Khodaei   +8 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Free vibration characteristics of functionally graded Mindlin nanoplates resting on variable elastic foundations using the nonlocal elasticity theory

Advances in Mechanical Engineering, 2018
In this research, free vibration behavior of thick functionally graded nanoplates is carried out using the Chebyshev spectral collocation method. It is assumed that the plates are resting on variable elastic foundations.
Ma’en S Sari, Mohammad Al-Rbai, Bashar R Qawasmeh   +2 more
doaj   +1 more source

Mechanical behaviour of functionally graded carbon nanofibre/phenolic nanocomposites: numerical modelling and experimental validation

, 2012
In this study, a finite element-based model was developed to investigate the mechanical behaviour of functionally graded carbon nanofibre (CNF)/phenolic nanocomposites. Four functionally graded nanocomposites (FGNs), a non-graded nanocomposite (NGN), and
Bafekrpour, E., Fox, B., Yang, C.
core  

Structural Integrity of Functionally Graded Composite Structure using Mindlin-Type Finite Elements. [PDF]

, 2008
In this paper, two new Mindlin-type plate bending elements have been derived for the modelling of functionally graded plate subjected to various loading conditions such as tensile loading, in-plane bending and out-of-plane bending.
El-Zafrany, A., Mba, David, Oyekoya, Oyedele O.   +2 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source