Results 61 to 70 of about 120,410 (255)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Influence of flexoelectric, small-scale, surface and residual stress on the nonlinear vibration of sigmoid, exponential and power-law FG Timoshenko nano-beams

Journal of Low Frequency Noise, Vibration and Active Control, 2019
This research deals with the nonlinear vibration of the functionally graded nano-beams based on the nonlocal elasticity theory considering surface and flexoelectric effects.
Mohammad Arefi, Mahmoud Pourjamshidian, Ali Ghorbanpour Arani, Timon Rabczuk   +3 more
doaj   +1 more source

Thermoelastic stability of thick imperfect functionally graded plates

Vietnam Journal of Mechanics, 2010
This paper investigates buckling of thick functionally graded plates with initial geometrical imperfection under thermal loadings. The equilibrium, stability, and compatibility equations of an imperfect functionally graded plate are derived using the ...
Hoang Van Tung, Nguyen Dinh Duc
doaj   +1 more source

Elastic-plastic analysis of functionally graded bars under torsional loading

, 2017
In this paper a new integral equation solution to the elastic-plastic problem of functionally graded bars under torsional loading is presented. The formulation is general in the sense that it can be applied to an arbitrary cross-section made of any type ...
Babouskos, Nick G., Tsiatas, George C.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Effects of thickness stretching in functionally graded plates and shells

, 2011
1The present work evaluates the effect of thickness stretching in plate/shell structures made by materials which are functionally graded (FGM) in the thickness directions.
Batra, Bayat, Birman, Brischetto, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Cauchy, Chi, Chi, Chiba, Estili, Ferreira, Haddadpour, Kashtalyan, Kashtalyan, Kirchhoff, Koizumi, Koizumi, Mindlin, Mori, Na, Pagano, Pagano, Pan, Poisson, Qian, Ramirez, Reissner, Vel, Vel, Zenkour   +37 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Equivalent layered models for functionally graded plates [PDF]

, 2016
Functionally graded plates whose material properties vary continuously through the thickness are modelled as exactly equivalent plates composed of up to four isotropic layers.
Alcazar Arevalo, F. J., Cheng, R. K. H., Kennedy, David, Wei, S.   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source