Results 81 to 90 of about 81,942 (347)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Stress concentration analysis in functionally graded plates with elliptic holes under biaxial
Ain Shams Engineering Journal, 2014 Stress concentration factors (SCFs) at the root of an elliptic hole in unidirectional functionally graded material (UDFGM) plates under uniaxial and biaxial loads are predicted. ANSYS Parametric Design Language (APDL) was used to build the finite element
Tawakol A. Enab
doaj +1 more source
Gradient design of metal hollow sphere (MHS) foams with density gradients [PDF]
, 2012 This is the post-print version of the final paper published in Composites Part B: Engineering. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
Liu, Y, Wang, B, Wu, H-X
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Vibration Analysis of Functionally Graded Carbon Nanotube Reinforced Beam Structures [PDF]
, 2015 This work deals with the study of vibration behavior of the Functionally Graded Timoshenko Beam that has been reinforced with Carbon Nanotubes (CNTs), which is subjected to thermal and mechanical loads.
Kumar , Nitish
core
, 2013 In this paper, the effect of local defects, viz., cracks and cutouts on the buckling behaviour of functionally graded material plates subjected to mechanical and thermal load is numerically studied.
Chakraborty, S +3 more
core +1 more source
Constitutive modelling and mechanical characterization of aluminium-based metal matrix composites produced by spark plasma sintering [PDF]
, 2010 Spark plasma sintering has been applied to the production of aluminium-based functionally graded material systems to be used in abrasive and high temperature conditions.
Bolzon, Gabriella +3 more
core +2 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Structural Integrity of Functionally Graded Composite Structure using Mindlin-Type Finite Elements. [PDF]
, 2008 In this paper, two new Mindlin-type plate bending elements have been derived for the modelling of functionally graded plate subjected to various loading conditions such as tensile loading, in-plane bending and out-of-plane bending.
El-Zafrany, A. +2 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source