Results 101 to 110 of about 6,143,449 (300)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Fundamental Movement Skills in Hong Kong Kindergartens: A Grade-Level Analysis

Education Sciences
Fundamental movement skills (FMSs) are essential building blocks for children’s physical development and future participation in physical activities. While early childhood curriculum frameworks recognize the importance of teaching FMSs, little research ...
Thomas Fan, Alfredo Bautista, Derwin K. C. Chan   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Mini-PlayLab model: A gamified approach to enhance motivation and fundamental movement skills

Journal Sport Area
Background: Physical education (PE) plays a critical role in supporting children’s physical, cognitive, social, and emotional development. However, PE instruction in elementary schools often remains teacher-centred and provides limited opportunities for
Wawan Syafutra, Ever Sovensi
doaj   +1 more source

Kontribusi Keterampilan Gerak Fundamental terhadap Keterampilan Bermain Small-Sided Handball Games

Jurnal Pendidikan Jasmani dan Olahraga, 2018
In doing physical activities, elementary school students tend to enjoy various types of games. Game activities consists of various movement skills and games skills that must be mastered by students in order to obtain success during the games. The purpose
Mei Fadilah, Ricky Wibowo
doaj   +1 more source

Associations of obesity, movement behaviors, and socioeconomic status with fundamental movement skills in children: Results from the REACT project

American Journal of Human Biology
To investigate the relationship of biological characteristics (age, sex, and obesity), movement behaviors (physical activity and sedentary time), and family socioeconomic status with fundamental movement skills (FMS) in primary school children.
Priscyla Praxedes, J. Maia, Carla Santos, Fernando Garbeloto, D. Hedeker, T. Barreira, R. Garganta, C. Farias, Go Tani, J. Chaput, D. Stodden, P. Katzmarzyk, S. Pereira   +12 more
semanticscholar   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Evaluating the Impact of a Laboratory-Based Program on Children’s Coordination Skills Using the MABC-2

Education Sciences
The aim of this study was to verify the effects of laboratory learning on children’s fundamental movement skills (FMS) through an intervention designed and implemented by specially trained generalist teachers.
Sara Aliberti, Tiziana D’Isanto, Francesca D’Elia   +2 more
doaj   +1 more source