Results 91 to 100 of about 201,996 (278)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Absolute Calibration. IV. Use of G-type Stars as Primary Calibrators

The Astronomical Journal
We demonstrate an approach to determine spectral energy distribution (SED) templates that are accurate to the 1% level from the visible through the infrared for nearby (unextincted) solar-type stars. Our approach is based only on measurements of T _eff ,
G. H. Rieke, Everett Schlawin, Charles R. Proffitt, Christopher Willmer   +3 more
doaj   +1 more source

B stars in open clusters: fundamental parameters [PDF]

, 2010
Y. Aidelman, L. S. Cidale, J. Zorec, M. L. Arias   +3 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

BSN. II. The First Light Curve Study of Eight Total Eclipsing Contact Binary Stars with Shallow Fillout Factors

The Astronomical Journal
This study provides the first comprehensive analysis of eight total-eclipse W Ursae Majoris-type contact binary systems. Ground-based photometric multiband observations were conducted at a Mexican observatory, and new times of minima were extracted.
Atila Poro, Kai Li, Raul Michel, Li-Heng Wang, Fahri Alicavus, Morgan Rhai Nájera, Priscila Santillán-Ortega, Francisco Javier Tamayo, Hector Aceves   +8 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Spectral classification of stars using synthetic model atmospheres [PDF]

, 2001
We devised a straightforward procedure to derive the atmosphere fundamental parameters of stars across the different MK spectral types by comparing mid-resolution spectroscopic observations with theoretical grids of synthetic spectra.The results of a ...
Bertone, E., Buzzoni, A.
core   +2 more sources

Spectroscopic monitoring of the Herbig Ae star HD 104237. II. Non-radial pulsations, mode analysis and fundamental stellar parameters

, 2011
Herbig Ae/Be stars are intermediate-mass pre-main sequence (PMS) stars showing signs of intense activity and strong stellar winds, whose origin is not yet understood in the frame of current theoretical models of stellar evolution for young stars.
A. Fumel, Acke, Anders, Baines, Bertout, Bouret, Breger, Breger, Böhm, Böhm, Böhm, Böhm, Böhm, Catala, Catala, Catala, Catala, Catala, Catala, Catala, Donati, Dupret, Dupret, Feigelson, Fuhr, Gilliland, Grady, Guimarães, Herbig, Hu, Hu, Iben, Iben, Kennelly, Kupka, Kupka, Kurtz, Kurtz, Kuschnig, Lenz, Lignieres, Luhman, Lyo, Malkov, Marconi, Meeus, Meléndez, Palla, Palla, Palla, Palla, Piskunov, Praderie, Praderie, Reegen, Ripepi, Ryabchikova, Siess, Smalley, Sousa, T. Böhm, Testa, van den Ancker, van den Ancker, Vick, Wade, Waters, Zima, Zima, Zwintz   +69 more
core   +1 more source

Spectroscopic and physical parameters of Galactic O-type stars. II. Observational constraints on projected rotational and extra broadening velocities as a function of fundamental parameters and stellar evolution [PDF]

, 2013
N. Markova, J. Puls, S. Simón‐Díaz, A. Herrero, H. Markov, N. Langer   +5 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source