Results 81 to 90 of about 14,824 (273)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

An Extremely Hot Pulsating Prewhite Dwarf from OGLE

The Astronomical Journal
We show that the blue 18.3 minutes variable object discovered in the Galactic disk by the OGLE-III survey and named OGLE-GD-WD-0001 is a pulsating prewhite dwarf of PG 1159 spectral type.
Paweł Pietrukowicz, Klaus Werner, Mateusz J. Mróz, Milena Ratajczak   +3 more
doaj   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Low-mass Eclipsing Binaries KIC 4908495, KIC 6466939, and KIC 9474485: Isolated Pre-main-sequence Systems?

The Astrophysical Journal
We present a detailed analysis of three Kepler eclipsing binaries, KIC 4908495, KIC 6466939, and KIC 9474485. Our analysis reveals that these systems are composed of components possessing a lower mass than our Sun with slight subsolar metallicities ...
Orkun Özdarcan
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Photometric and Spectroscopic Studies of Two Early-type Eclipsing Binaries

The Astrophysical Journal
Using high-precision photometric data from the Transiting Exoplanet Survey Satellite, medium-resolution spectroscopic data from the Large Sky Area Multi-Object Fiber Spectroscopy Telescope, and long-term eclipse timings, we provide orbital parameters for
Pengfei Ye, Kai Li, Fei Liu, Xiang Gao, Jing-Yi Wang   +4 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

OO Leo: An Active Contact Binary with Possible Solar-like Differential Rotation

The Astrophysical Journal
With Transiting Exoplanet Survey Satellite (TESS) high-precision photometry and Large Sky Area Multi-object Fiber Spectroscopic Telescope medium-resolution spectra, we present the first light and radial velocity curve analyses for the eclipsing binary OO
Zi-Bin Meng, Pei-Ru Wu, Yun-Xia Yu, Ke Hu, Fu-Yuan Xiang   +4 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source