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What Are the Functions of Chitin Deacetylases in Aspergillus fumigatus?
Frontiers in Cellular and Infection Microbiology, 2020 Deacetylation of chitin by chitin deacetylases (Cda) results in the formation of chitosan. Chitosan, a polymer of β1,4 linked glucosamine, plays multiple roles in the function of the fungal cell wall, including virulence and evasion of host immune ...
Isabelle Mouyna +15 more
doaj +1 more source
Inhibitors against Fungal Cell Wall Remodeling Enzymes [PDF]
ChemMedChem, 2017 AbstractFungal β‐1,3‐glucan glucanosyltransferases are glucan‐remodeling enzymes that play important roles in cell wall integrity, and are essential for the viability of pathogenic fungi and yeasts. As such, they are considered possible drug targets, although inhibitors of this class of enzymes have not yet been reported.
Ignacio Delso +9 more
openaire +4 more sources
New cell wall-affecting antifungal antibiotics [PDF]
, 2013 Capítulo 9.Fungi have emerged worldwide as increasingly frequent causes of healthcare-associated infections. Invasive fungal infections can be life-threatening.
Cortés, Juan Carlos G. +2 more
core +2 more sources
mBio, 2018 Aspergillus fumigatus mitogen-activated protein kinases (MAPKs) are involved in maintaining the normal morphology of the cell wall and providing resistance against cell wall-damaging agents.
Leandro José de Assis +11 more
doaj +1 more source
Diversity of Cell Wall Related Proteins in Human Pathogenic Fungi
Journal of Fungi, 2017 The cell wall is one of the major keys to fungal identity. Fungi use their cell wall to sense the environment, and localize nutrients and competing microorganism. Pathogenic species additionally modify their cell walls to hide from a host’s immune system.
Anna Muszewska +3 more
doaj +1 more source
mBio, 2021 This study provides new insights into the complex evolutionary history of the fungal cell wall. We analyzed fungal enzymes that convert sugars acquired from the environment into the diverse sugars that make up the fundamental building blocks of the cell ...
Julian Schwerdt +4 more
doaj +1 more source
Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers [PDF]
, 2018 This work was supported by the Fundação Carlos Chagas de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), grants E-26/202.974/2015 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), grants 229755/2013-5, Brazil.
A Chakrabarti +69 more
core +4 more sources
Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen [PDF]
, 2012 The survival of all microbes depends upon their ability to respond to environmental challenges. To establish infection, pathogens such as Candida albicans must mount effective stress responses to counter host defences while adapting to dynamic changes in
Adya, Ashok K. +6 more
core +3 more sources
mSphere, 2019 Regulation of fungal cell wall biosynthesis is critical to maintain cell wall integrity in dynamic fungal infection microenvironments. Genes involved in this response that impact fungal fitness and host immune responses remain to be fully defined.
Arsa Thammahong +4 more
doaj +1 more source