Results 11 to 20 of about 208,417 (290)
Architecture of the dynamic fungal cell wall
Nature Reviews Microbiology, 2022 The fungal cell wall is essential for growth and survival, and is a key target for antifungal drugs and the immune system. The cell wall must be robust but flexible, protective and shielding yet porous to nutrients and membrane vesicles and receptive to exogenous signals.
Neil A. R. Gow, Megan D. Lenardon
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mBio, 2018 The fungal cell wall is a critically important structure that represents a permeability barrier and protective shield. We probed Candida albicans and Cryptococcus neoformans with liposomes containing amphotericin B (AmBisome), with or without 15-nm ...
Louise Walker +9 more
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Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance [PDF]
mBio, 2015 The fungal cell wall confers cell morphology and protection against environmental insults. For fungal pathogens, the cell wall is a key immunological modulator and an ideal therapeutic target.
Iuliana V. Ene +8 more
doaj +6 more sources
Fungal cell wall components modulate our immune system. [PDF]
Cell Surf, 2021 Invasive fungal infections remain highly problematic for human health. Collectively, they account for more than 1 million deaths a year in addition to more than 100 million mucosal infections and 1 billion skin infections. To be able to make progress it is important to understand the pathobiology of fungal interactions with the immune system.
Briard B +4 more
europepmc +6 more sources
Cryptococcus neoformans chitin synthase 3 plays a critical role in dampening host inflammatory responses [PDF]
, 2020 Cryptococcus neoformans is the most common disseminated fungal pathogen in AIDS patients, resulting in ∼200,000 deaths each year. There is a pressing need for new treatments for this infection, as current antifungal therapy is hampered by toxicity and/or
Hole, Camaron R +3 more
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Autolytic Enzymes in Fungal Cell Walls [PDF]
Journal of General Microbiology, 1966 SUMMARY: Autolytic glucanase and protease activity was detected in cell walls of some pythium species prepared by ultrasonic treatment. The glucanase activity was correlated with mycelial development. Maximal glucose release was detected in growing cultures during the linear growth period of the fungus.
R, Mitchell, N, Sabar
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Characterization of Extracellular Vesicles Produced by
mSphere, 2020 Extracellular vesicles (EVs) are membranous compartments produced by yeast and mycelial forms of several fungal species. One of the difficulties in perceiving the role of EVs during the fungal life, and particularly in cell wall biogenesis, is caused by ...
Juliana Rizzo +9 more
doaj +3 more sources
Immunoreactivity of the fungal cell wall [PDF]
Medical Mycology, 2001 The cell wall is the major fungal structure involved in the interaction with the host and most of the immunological effects observed with intact fungal cells have been reproduced with cell-wall components. As a result of the exposure to fungal antigens, most individuals develop both cellular and antibody responses intended to limit the invasiveness or ...
J, Pontón +4 more
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mBio, 2020 The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of immunocompromised humans. The mitogen-activated protein kinase (MAPK)
Eliciane Cevolani Mattos +16 more
doaj +1 more source
FGB1 and WSC3 are in planta-induced beta-glucan-binding fungal lectins with different functions [PDF]
, 2019 In the root endophyte Serendipita indica, several lectin-like members of the expanded multigene family of WSC proteins are transcriptionally induced in planta and are potentially involved in beta-glucan remodeling at the fungal cell wall.
Becker, S. +8 more
core +2 more sources