Results 51 to 60 of about 11,622 (186)

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease

Gut Microbes
The gut mycobiome significantly affects host health and immunity. However, most studies have focused on symbiotic bacteria in the gut microbiome, whereas less attention has been given to symbiotic fungi.
Hui Huang, Qiurong Wang, Ying Yang, Wei Zhong, Feng He, Jun Li   +5 more
doaj   +1 more source

Forecasting Root Rot Disease through Predictive Microbial Functional Profiling

Advanced Science, EarlyView.
Predicting soil‐borne disease moves beyond observation with a framework that elevates microbial functional genes into reliable forecasting biomarkers. By coupling targeted qPCR assays for core stress‐response genes with machine learning, this method detects root rot risks in pre‐symptomatic soils with over 80% accuracy.
Chuan You, Peng Ren, Ying Guan, Kai Gong, Zhen Hua, Wuxian Zhou, Xinlan Mei, Yikui Wang, Xiaofang Wang, Yangchun Xu, Qirong Shen, Zhong Wei   +11 more
wiley   +1 more source

Antibiotic Treatments for Clostridium difficile Infection Are Associated with Distinct Bacterial and Fungal Community Structures

mSphere, 2018
Clostridium difficile infection (CDI) is the most common nosocomial infection in the United States, being associated with high recurrence and persistence rates.
Regina Lamendella, Justin R. Wright, Jada Hackman, Christopher McLimans, David R. Toole, William Bernard Rubio, Rebecca Drucker, Hoi Tong Wong, Kate Sabey, John P. Hegarty, David B. Stewart   +10 more
doaj   +1 more source

Alterations in the gut bacterial microbiome in fungal Keratitis patients. [PDF]

PLoS ONE, 2018
Dysbiosis in the gut microbiome has been implicated in several diseases including auto-immune diseases, inflammatory diseases, cancers and mental disorders.
Sama Kalyana Chakravarthy, Rajagopalaboopathi Jayasudha, Konduri Ranjith, Anirban Dutta, Nishal Kumar Pinna, Sharmila S Mande, Savitri Sharma, Prashant Garg, Somasheila I Murthy, Sisinthy Shivaji   +9 more
doaj   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Alterations of gut mycobiota profiles in intrahepatic cholangiocarcinoma

Frontiers in Microbiology, 2023
ObjectiveIntrahepatic cholangiocarcinoma (ICC) is a silent liver malignancy with an increasing incidence. Gut mycobiota plays a crucial role in benign liver diseases; however, its correlation with ICC remains elusive. This study aimed to elucidate fungal
Lilong Zhang, Lilong Zhang, Lilong Zhang, Chen Chen, Chen Chen, Chen Chen, Dongqi Chai, Dongqi Chai, Dongqi Chai, Tianrui Kuang, Tianrui Kuang, Tianrui Kuang, Wenhong Deng, Wenhong Deng, Wenhong Deng, Weixing Wang, Weixing Wang, Weixing Wang   +17 more
doaj   +1 more source