Results 71 to 80 of about 19,745 (223)

The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease

Gut Microbes
The gut mycobiome significantly affects host health and immunity. However, most studies have focused on symbiotic bacteria in the gut microbiome, whereas less attention has been given to symbiotic fungi.
Hui Huang, Qiurong Wang, Ying Yang, Wei Zhong, Feng He, Jun Li   +5 more
doaj   +1 more source

Microbiota signatures in type-2 diabetic patients with chronic kidney disease - A Pilot Study [PDF]

, 2019
The human microbiota is paramount for normal host physiology. Altered host-microbiome interactions are part of the pathogenesis of numerous common ailments.
Chifiriuc, Mariana Carmen, Gradisteanu, Gratiela P., Petcu, Laura, Picu, Ariana, Salmen, Teodor, Serafinceanu, Cristian, Stefan, Diana S., Stoian, Anca P., Stoica, Roxana A., Suceveanu, Adrian P.   +9 more
core   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Gut Mycobiome and Asthma

Journal of Fungi
This review explores the ‘gut–lung axis’ in asthma with a focus on commensal fungal organisms. We explore how changes to the intestinal commensal fungal community composition alter lung immune function.
Amjad N. Kanj, Joseph H. Skalski
doaj   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

The role of the gut mycobiota in neurodevelopmental disorders: a multikingdom disruption of the gut-brain axis

Frontiers in Microbiology
Research on the gut-brain axis in neurodevelopmental disorders (NDDs) has historically focused on bacteria, overlooking fungal contributions. This review synthesizes emerging evidence to propose that intestinal fungi may actively contribute to NDD ...
Yue Hu, Yue Hu, Xiao-Li Yu, Xia-Jing Zhang, Li-Tian Ma, Li-Tian Ma, Li-Tian Ma   +6 more
doaj   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Antibiotic Treatments for Clostridium difficile Infection Are Associated with Distinct Bacterial and Fungal Community Structures

mSphere, 2018
Clostridium difficile infection (CDI) is the most common nosocomial infection in the United States, being associated with high recurrence and persistence rates.
Regina Lamendella, Justin R. Wright, Jada Hackman, Christopher McLimans, David R. Toole, William Bernard Rubio, Rebecca Drucker, Hoi Tong Wong, Kate Sabey, John P. Hegarty, David B. Stewart   +10 more
doaj   +1 more source

Fungi at the scene of the crime: innocent bystanders or accomplices in oral infections? [PDF]

, 2018
Purpose of Review: Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections.
Delaney, Christopher, Kean, Ryan, McLean, William, Nile, Christopher, Ramage, Gordon, Short, Bryn, Tumelty, Maria   +6 more
core   +2 more sources

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source