Results 71 to 80 of about 37,838,535 (141)

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Sampriti Paul, Sonal Dubey, Prashant Tiwari   +2 more
wiley   +1 more source

17βH-Periplogenin, a cardiac aglycone from the root bark of Periploca sepium Bunge

Acta Crystallographica Section E, 2012
The title compound {systematic name: 4-[(3S,5S,8R,9S,10R,13R,14S,17S)-3,5,14-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]furan-2(5H)-one}, C23H34O5, was isolated from the roots of Periploca sepium Bunge, a famous Chinese ...
Yu-Wei Zhang, Yong-Li Bao, Yin Wu, Chun-Lei Yu, Yu-Xin Li   +4 more
doaj   +1 more source

Update of the risk assessment on emerging and novel brominated flame retardants in food

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to update its 2012 risk assessment on Emerging and Novel brominated flame retardants (BFRs) in food. Since the previous Opinion, further information was collected for a total of 27 BFRs. The CONTAM Panel concluded that TDBPP, DBPNG and TBNPA are considered genotoxic and carcinogenic.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Emilio Benfenati, Diane Benford, Andy Hart, Martin Rose, Henri Schroeder, Christiane Vleminckx, Martine Vrijheid, Edoardo Carnesecchi, Violetta Costanzo, Andrea Gissi, Eirini Kouloura, Luisa Ramos Bordajandi, Francesca Riolo, Christer Hogstrand   +33 more
wiley   +1 more source

3,6-Di(furan-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione and bithiophene copolymer with rather disordered chain orientation showing high mobility in organic thin film transistors

, 2011
Pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione or diketopyrrolopyrrole (DPP) is a useful electron-withdrawing fused aromatic moiety for the preparation of donor-acceptor polymers as active semiconductors for organic electronics.
Wenjin Zeng, Sonar, Prashant, Samarendra P. Singh, Yuning Li, Li, Y., Prashant Sonar, Zeng, W., Mui Siang Soh, Singh, S. P., Soh, M. S.   +9 more
core   +1 more source

Multicomponent Approach to the Synthesis of 4-(1H-indol-3-yl)-5-(4-methoxyphenyl)furan-2(5H)-one

, 2021
A simple one-pot approach was developed for the synthesis of furan-2(5H)-one derivative containing indole fragments. This method includes the telescoped multicomponent reaction of indole, 4-methoxyphenylglyoxal, and Meldrum’s acid.
Valeriya G. Melekhina, Boris V. Lichitsky, Andrey N. Komogortsev   +2 more
core   +1 more source

Pd‐Catalyzed Cyclotrimerization and Cycloaddition of 5,6‐Didehydrobenzo[8]annulenes (BenzoCOTynes): Formation of Nonplanar Tri[8]annulenes and Diels–Alder Cycloadducts

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
A Pd(0)‐catalyzed cyclotrimerization of benzoCOTynes to form tri(benzo[8]annulenes) was developed. Three distinct isomers were isolated and structurally characterized by single‐crystal X‐ray diffraction. Ligand modulation proved crucial for enhancing regioselectivity: P(4‐OMePh), and (S)‐tBu‐Phox promoted the formation of the symmetric isomers.
Jesús Bello‐García, Jesús A. Varela, Carlos Saá   +2 more
wiley   +1 more source

An expeditious synthesis of 4-aryl-γ-butyrolactones, -furan-2(5H)-ones and -5-alkoxyfuran-2(5H)-ones via Heck-reaction of arenediazonium salts with 2,5-dihydrofuran

, 1996
An exceptionally simple and short synthetic sequence to 4-substituted furan-2(5H)-ones involving a Heck reaction on 2,5-dihydrofuran and subsequent iterative NBS oxidation is ...
Sengupta, Saunitra, Mehta, Goverdhan
core   +1 more source

Las furan-2[5H]-onas (?a,ß-butenolidas), su preparación e importancia biológica [PDF]

, 2015
Furan-2[5H]-ones (?a,ß-butenolides): preparation and biological significance. Heterocyclic systems are one of the most versatile areas in organic chemistry. The five members oxacyclic system of furan-2[5H]-ones, commonly named as ?a,ß-butenolides, are of
Urbina González, Juan Manuel, León, Andrés   +1 more
core  

Correction: Masi et al. Araufuranone: A New Phytotoxic Tetrasubstituted Dihydrofuro[3,2-b]furan-2(5H)-One Isolated from Ascochyta araujiae. Biomolecules 2022, 12, 1274. [PDF]

Biomolecules, 2023
Masi M, Boari A, Sautua F, Carmona MA, Vurro M, Evidente A.   +5 more
europepmc   +1 more source

Catalytic Double Cyclization Process for Antitumor Agents against Breast Cancer Cell Lines

iScience, 2018
Summary: The development of efficient synthetic strategies for the discovery of novel antitumor molecules is a major goal in current research. In this context, we report here a catalytic double cyclization process leading to bicyclic heterocycles with ...
Raffaella Mancuso, Ida Ziccarelli, Adele Chimento, Nadia Marino, Nicola Della Ca’, Rosa Sirianni, Vincenzo Pezzi, Bartolo Gabriele   +7 more
doaj   +1 more source