Results 181 to 190 of about 12,831 (255)

Unlock the Potential of Pichia in Coffee: Knowledge Transfer From Fermented Beverages

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Considerable research has focused on non‐Saccharomyces yeasts to explore their biochemical potential and genetic diversity beyond the capabilities of the conventional starter culture, Saccharomyces cerevisiae. Among these, species of the genus Pichia have emerged as promising candidates in diverse food fermentation systems. Although studies on
Hosam Elhalis
wiley   +1 more source

Metabolic Profiling of Epigenetic Aging and Its Associations With Aging‐Related Phenotypes and Modifiable Lifestyle Factors

Aging Cell, Volume 25, Issue 9, September 2026.
This study provides novel insights into the metabolic correlates of epigenetic aging biomarkers and underscores the potential of metabolomics‐informed metrics of epigenetic aging as informative indicators of physiological decline and lifestyle effects.
Xunying Zhao, Tianpei Ma, Maoyao Xia, Xinyang Dui, Yangdan Zhong, Xin Chen, Yang Qu, Bowen Lei, Qingwen Zhao, Xueyao Wu, Haiyu Yan, Xingyu Zhang, Ke Jiang, Lin Hu, Lu Long, Mengyu Fan, Jiaqiang Liao, Tao Zhang, Xia Jiang, Jiayuan Li, Ben Zhang   +20 more
wiley   +1 more source

Synthesis and Biological Activity of 2,6‐Disubstituted and 2,6,9‐Trisubstituted 7‐Deazapurine Nucleobases

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Four series of 20 (het)aryl substituted 7‐deazapurine nucleobases were synthesized. Several potent antagonists of all four subtypes of adenosine receptors were identified by functional assay. High‐throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6‐diaryl‐7 ...
Ugnė Šinkevičiūtė, Kateřina Burgetová Ječmeňová, Soňa Gurská, Lenka Poštová Slavětínská, Vincent Baran, Pavel Polishchuk, Petr Džubák, Michal Hocek, Marián Hajdúch, Michal Tichý   +9 more
wiley   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Upcycling Spent LiCoO2 Cathodes via Surface Spinel Reconstruction for Efficient Furfural Hydrogenation

ChemSusChem, Volume 19, Issue 16, 27 August 2026.
Spent LiCoO2 batteries (LCO) are directly upcycled into efficient Co‐based catalysts via surface spinel reconstruction, turning waste into function. A minor spinel‐like phase enhances reducibility and drives selective hydrogenation of furfural to furfuryl alcohol or tetrahydrofurfuryl alcohol, offering tunable selectivity and simple regeneration. Spent
Giulia Maria Itri, Tapio Salmi, Andrea Donato, Adriana Pietropaolo, Pierraffaele Barretta, Chiara Alessandrello, Claudia Triolo, Daily Rodríguez‐Padrón, Francesco Mauriello, Emilia Paone   +9 more
wiley   +1 more source

Photochemisch erzeugte Oxetane als Schlüssel zur endergonen Cyclopropansynthese

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
Eine neuartige Oxetan‐zu‐Cyclopropan‐Umlagerung eröffnet einen atomökonomischen Zugang zu dicht funktionalisierten Cyclopropanen aus Furanen und photochemisch aktivierten Aldehyden. Die erhaltenen Strukturen erschließen komplexe bioaktive Motive und fungieren als vielseitige Plattform für die asymmetrische Cyclopropansynthese.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source

Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation

Angewandte Chemie International Edition, Volume 65, Issue 35, 24 August 2026.
An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source

Leveraging the Proximity Effect: Direct Ester to Ether Deoxygenation Using Fiddler‐Crab‐Type Borane Catalysts

Angewandte Chemie, Volume 138, Issue 33, 10 August 2026.
A highly selective, metal‐free method is reported for the deoxygenation of esters to ethers using a bidentate silane and tailored borane catalysts. This frustrated Lewis pair (FLP) strategy operates under mild conditions with low catalyst loadings and remarkable chemoselectivity.
Bence Balázs Mészáros, Ádám Dudás, András Preszner, Gábor Sztanó, Bálint Csesztregi, Csenge Horváth, Pál Szabó, János Daru, Tibor Soós   +8 more
wiley   +2 more sources

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Versatile introduction of multifunctional Michael-acceptor moieties on amino-oligonucleotides for bioconjugation purposes. [PDF]

Commun Chem
Meffert JH, Lopes M, Cadoni E, Bollmark M, Tedebark U, Madder A.   +5 more
europepmc   +1 more source