Results 81 to 90 of about 27,241 (159)

Functional and Multi-Omics Effects of an Optimized CRISPR-Mediated FURIN Depletion in U937 Monocytes

Cells
The pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and cardiovascular diseases.
Ruiming Chua, Lijin Wang, Roshni Singaraja, Sujoy Ghosh   +3 more
doaj   +1 more source

Furin inhibits HSCs activation and ameliorates liver fibrosis by regulating PTEN‐L/PINK1/parkin mediated mitophagy in mouse

FASEB BioAdvances
Hepatic Stellate cells (HSCs) play an important role during liver fibrosis progression; more and more evidence indicates that mitophagy greatly regulates HSCs activation.
Yan‐Wei Song, Yu‐Hua Zhu, Ming‐Ze Ma   +2 more
doaj   +1 more source

Influence of organic solvents on the furin activity

The Ukrainian Biochemical Journal, 2018
Furin belongs to a family of calcium-dependent serine proprotein convertases, which transform the inactive protein precursors into mature polypeptides.
T. V. Osadchuk, O. V. Shybyryn, A. V. Semyroz, V. K. Kibirev   +3 more
doaj   +1 more source

Effect of iron overload on furin expression in wild-type and β-thalassemic mice

Toxicology Reports, 2015
Furin is a proprotein convertase enzyme. In the liver, it cleaves prohepcidin to form active hepcidin-25, which regulates systemic iron homeostasis. Hepcidin deficiency is a component of several iron overload disorders, including β-thalassemia.
Surasak Wichaiyo, Paranee Yatmark, Ronald Enrique Morales Vargas, Pimtip Sanvarinda, Saovaros Svasti, Suthat Fucharoen, Noppawan Phumala Morales   +6 more
doaj   +1 more source

Streptococcus endopeptidases promote HPV infection in vitro

MicrobiologyOpen, 2019
Both cervical and throat cancers are associated with human papillomavirus (HPV). HPV infection requires cleavage of the minor capsid protein L2 by furin.
Sylvia I. Pavlova, Reid V. Wilkening, Michael J. Federle, Yu Lu, Joel Schwartz, Lin Tao   +5 more
doaj   +1 more source

Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma

Nature Communications
Receptor binding of TGF-β and related ligands such as Activin-A requires cleavage of a furin site in their dimeric precursor proteins. Melanoma cells cleave one Activin-A subunit independently of furin and related proprotein convertases, raising ...
Manon Bulliard, Katarina Pinjusic, Laura Iacobucci, Céline Schmuziger, Nadine Fournier, Daniel B. Constam   +5 more
doaj   +1 more source

The dual actions of miRNA16a in restricting Bovine Coronavirus replication through downregulation of Furin and enhancing the host immune response

Scientific Reports
The roles of host cell miRNAs have not been well studied in the context of BCoV replication and immune regulation. This study aimed to identify miRNA candidates that regulate essential host genes involved in BCoV replication, tissue tropism, and immune ...
Abid Ullah Shah, Maged Gomaa Hemida
doaj   +1 more source

Furin [PDF]

, 2020
openaire   +1 more source

Quantitative Characterization of Furin Specificity [PDF]

Journal of Biological Chemistry, 1999
Damian J. Krysan, Nathan C. Rockwell, Robert S. Fuller   +2 more
openaire   +1 more source

FURIN Gene [PDF]

, 2020
openaire   +1 more source