Results 51 to 60 of about 69,664 (311)

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Mechanism of NaCl transport-stimulated prostaglandin formation in MDCK cells [PDF]

, 1987
Recently we have found that stimulation of NaCl transport in high-resistance MDCK cells enhances their prostaglandin formation. In the present study, we investigated the mechanisms by which prostaglandin formation could be linked to the ion transport in ...
Bauer, C., Kurtz, Armin, Malmström, K., Pfeilschifter, J., Woodson, R. D.   +4 more
core   +1 more source

A Case Series of Valve‐in‐Valve Transcatheter Aortic Valve Replacement in Stentless Bioprosthetic Valves Using Self‐Expanding Platform With Minimalist Approach

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Valve‐in‐valve (ViV) Transcatheter aortic valve replacement (TAVR) has emerged as a valid treatment option in symptomatic patients with failed aortic bioprosthetic valves, most especially in those with intermediate, high or prohibitive risk of surgery. Due to the unique design of stentless bioprosthetic valves with absence of visible posts and
Adeogo Akinwale Olusan, Raj Rajendra, Elved Roberts, Jan Kovac   +3 more
wiley   +1 more source

Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects – a randomized controlled trial

BMC Nephrology, 2019
Background Chloride is speculated to have nephrotoxic properties. In healthy subjects we tested the hypothesis that acute chloride loading with 3% saline would induce kidney injury, which could be prevented with the loop-diuretic furosemide.
F. H. Mose, A. N. Jörgensen, M. H. Vrist, N. P. Ekelöf, E. B. Pedersen, J. N. Bech   +5 more
doaj   +1 more source

Cellular mechanisms of potassium homeostasis in the mammalian nervous system [PDF]

, 1987
Double-barrelled ion-sensitive microelectrodes were used to measure changes in the intracellular activities of K+, Na+, and Cl- (aKi, aNai, aCli) in neurones of rat sympathetic ganglia and in glial cells of slices from guinea-pig olfactory cortex.
Ballanyi, Klaus, Grafe, Peter
core   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Association between furosemide administration and outcomes in critically ill patients with acute kidney injury

Critical Care, 2020
Background Although current guidelines for AKI suggested against the use of furosemide in AKI management, the effect of furosemide on outcomes in real-world clinical settings remains uncertain.
Guang-ju Zhao, Chang Xu, Jian-chao Ying, Wen-biao Lü, Guang-liang Hong, Meng-fang Li, Bing Wu, Yong-ming Yao, Zhong-qiu Lu   +8 more
doaj   +1 more source

Identifying Candidate Risk Factors for Prescription Drug Side Effects using Causal Contrast Set Mining [PDF]

, 2015
Big longitudinal observational databases present the opportunity to extract new knowledge in a cost effective manner. Unfortunately, the ability of these databases to be used for causal inference is limited due to the passive way in which the data are ...
Aickelin, Uwe, Guo, Zhaoyang, Reps, Jenna, Zhu, Haoyue   +3 more
core   +3 more sources

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Emerging pharmacotherapy of tinnitus [PDF]

, 2009
Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life.
Ana Belén Elgoyhen, Azevedo AA, Bahmad FM, Berthold Langguth, Busto U, Courtney KR, Domeisen H, Feder R, Gananca MM, Goebel G, Goodnick PJ, Gresser U, Guitton MJ, Guitton MJ, Hastak SM, Henry JA, Hilton M, Holstein N, House JW, Kuchar DL, Langguth B, Lenarz T, Mahadevan S, Mardini MK, McCabe BF, Melcher JR, Moller AR, Moller AR, Newman CW, Oliver D, Podoshin L, Richard Salvi, Rogawski MA, Roth SH, Schlee W, Shambaugh GE, Shea JJ, Shulman A, Sieghart W, Tandon R, Wei BPC, Williams SH, Willow M, Zapp JJ   +43 more
core   +1 more source