Results 61 to 70 of about 77,789 (337)

Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur, Jashvant D. Unadkat, Emily E. Fay, Nina Isoherranen, Mary F. Hebert   +4 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes

Drug Testing and Analysis, EarlyView.
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug, S. Guddat, C. Görgens, K. Walpurgis, F. Toma, A. Thomas, M. Thevis   +6 more
wiley   +1 more source

Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects – a randomized controlled trial

BMC Nephrology, 2019
Background Chloride is speculated to have nephrotoxic properties. In healthy subjects we tested the hypothesis that acute chloride loading with 3% saline would induce kidney injury, which could be prevented with the loop-diuretic furosemide.
F. H. Mose, A. N. Jörgensen, M. H. Vrist, N. P. Ekelöf, E. B. Pedersen, J. N. Bech   +5 more
doaj   +1 more source

Response to different furosemide doses predicts AKI progression in ICU patients with elevated plasma NGAL levels

Annals of Intensive Care, 2018
BackgroundFurosemide responsiveness (FR) is determined by urine output after furosemide administration and has recently been evaluated as a furosemide stress test (FST) for predicting severe acute kidney injury (AKI) progression.
Ryo Matsuura, Y. Komaru, Y. Miyamoto, Teruhiko Yoshida, Kohei Yoshimoto, Rei Isshiki, Kengo Mayumi, Tetsushi Yamashita, Y. Hamasaki, M. Nangaku, E. Noiri, N. Morimura, Kent Doi   +12 more
semanticscholar   +1 more source

Outpatient treatment of decompensated heart failure: A systematic review and study level meta‐analysis

ESC Heart Failure, Volume 12, Issue 2, Page 761-769, April 2025.
Abstract Patients with acutely decompensated heart failure (ADHF) are usually admitted to hospital for management. There is growing interest in delivering intravenous (IV) diuretic therapy at home, in the community or at hospital day‐care units; the safety and effectiveness of outpatient‐based management (OPM) for ADHF has not been established.
Jameela Bahar, Amna Rahman, Grace W.Y. Wong, Rajiv Sankaranarayanan, Fozia Z. Ahmed, Rebecca Taylor, Ahmet Fuat, Iain Squire, John G.F. Cleland, Gregory Y.H. Lip, James H.P. Gamble, Sundas Masudi, Prince Josiah S. Joseph, Kenneth Y.K. Wong   +13 more
wiley   +1 more source

Tolvaptan vs. furosemide‐based diuretic regimens in patients hospitalized for heart failure with hyponatremia (AQUA‐AHF)

ESC Heart Failure, 2020
Aims Hyponatremia is associated with poorer outcomes and diuretic response in patients hospitalized for heart failure. This study compared a tolvaptan‐based vs.
Tien M.H. Ng, Luanda P. Grazette, Michael W. Fong, Andrew J. Yoon, Mimi Lou, Allen Kuo, Rani Y. Upadhyay, Emily E. Han, Anilkumar Mehra, Uri Elkayam   +9 more
doaj   +1 more source

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Secondary to Furosemide: Case Report and Review of Literature

The American journal of case reports, 2018
Patient: Male, 63 Final Diagnosis: DRESS syndrome Symptoms: Diarrhea • fever • rash • shortness of breath Medication: Furosemide Clinical Procedure: Skin biopsy Specialty: Internal Medicine • Family Medicine Objective: Rare disease Background: DRESS is a
Jared James, Y. Sammour, A. Virata, T. Nordin, I. Dumic   +4 more
semanticscholar   +1 more source

MELD score predicts outcomes in patients with advanced heart failure: A longitudinal evaluation

ESC Heart Failure, Volume 12, Issue 2, Page 839-847, April 2025.
Abstract Aims Advanced heart failure (AHF) is characterized by recurrent episodes of haemodynamic instability and frequent hospitalizations, leading to a progressive decline in quality of life and high mortality rates. The objectives of this study were to evaluate the effect of the model for end‐stage liver disease (MELD) score and its variations in ...
Francesco Curcio, Cristiano Amarelli, Rosaria Chiappetti, Irene Mattucci, Veronica Flocco, Mahmoud Issa Rammal, Ciro Abete, Francesca Mazzella, Ciro Maiello, Pasquale Abete, Francesco Cacciatore   +10 more
wiley   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Effect of furosemide in the treatment of high-altitude pulmonary edema

BMC Pulmonary Medicine
Background High-altitude pulmonary edema (HAPE) refers to the onset of breathlessness, cough, and fever at rest after arriving at high altitudes. It is a life-threatening illness caused by rapid ascent to high altitudes.
Dava Tenzing, Pianduo Suolang, Deji Gesang, Duoji Suolang, Gaozhan Duan, Wangmu Ciren, Yihui Wang, Tongtian Ni   +7 more
doaj   +1 more source