Results 101 to 110 of about 1,247,959 (250)

Fusión conceptual y analogía [PDF]

In this text it is exposed the theory of mental blending, which supposes an advance on the bipolar theory of projection. In mental blending theory they exist four different domains which interact in different alignments and blendings, unifying diverse ...
Fauconnier, Gilles
core   +1 more source

Trajectory Reconstruction Techniques for Evaluation of ATC Systems [PDF]

, 2008
This paper is focused on trajectory reconstruction techniques for evaluating ATC systems, using real data of recorded opportunity traffic. We analyze different alternatives for this problem, from traditional interpolation approaches based on curve ...
Besada Portas, Juan Alberto, García-Herrero, Jesús, Miguel Vela, Gonzalo de, Soto Jaramillo, Andrés, Tarrío Alonso, Paula   +4 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Reseña de una interpretación de discordia cuántica

Ciencia Ergo Sum, 2019
Se documenta la existencia de correlaciones tanto clásicas como cuánticas en sistemas de partículas. El entrelazamiento cuántico es la más famosa de las correlaciones cuánticas.
Manuel Ávila Aoki, Fabián Soberanes Martín   +1 more
doaj   +1 more source

The level of non-thermal velocity fluctuations deduced from Doppler spectroscopy and its role on TJ-II confinement

, 2009
The goal of this investigation is to study, in the line of previous works, the level of velocity fluctuations in different scenarios of the TJ-II stellarator.
Baciero, Dinklage, Landi, McCarthy, Rapisarda, Rapisarda, Zurro   +6 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Microcalorimetría diferencial de multifilamentos texturados de poliéster. Parte 1. Análisis de las endotermas de fusión mediante un programa interactivo basado en las funciones Spline. [PDF]

, 1982
La fusión de un material polimérico estructuralmente complejo, da lugar a termogramas en los que sobre la endoterma principal de fusión aparecen otras endotermas.
Canal Arias, José María, Gacén Guillén, Joaquín   +1 more
core   +1 more source