Results 91 to 100 of about 3,882,403 (320)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Recent diagnostic developments at the 100 kJ-level laser facility in China

open access: yesMatter and Radiation at Extremes, 2020
A 100 kJ-level laser facility has been designed to study inertial confinement fusion physics in China. This facility incorporates various diagnostic techniques, including optical, x-ray imaging, x-ray spectrum, and fusion product diagnostics, as well as ...
Feng Wang   +22 more
doaj   +1 more source

4D Multi-atlas Label Fusion using Longitudinal Images

open access: yes, 2017
Longitudinal reproducibility is an essential concern in automated medical image segmentation, yet has proven to be an elusive objective as manual brain structure tracings have shown more than 10% variability.
Huo, Yuankai   +2 more
core   +1 more source

Measurable residual disease analysis in paediatric acute lymphoblastic leukaemia patients with ABL-class fusions [PDF]

open access: hybrid, 2022
Nicola C. Venn   +21 more
openalex   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

The relative Drinfeld commutant of a fusion category and $\alpha$-induction

open access: yes, 2017
We establish a correspondence among simple objects of the relative commutant of a full fusion subcategory in a larger fusion category in the sense of Drinfeld, irreducible half-braidings of objects in the larger fusion category with respect to the fusion
Kawahigashi, Yasuyuki
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Study of Synergetic Effect of X2 and X3 EC Wave in KSTAR

open access: yesEPJ Web of Conferences, 2015
An experimental study of the X-mode absorption at the second and the third harmonic frequencies has been performed in KSTAR tokamak. The X2 EC frequency is 110 GHz and the X3 EC frequency is 170 GHz at the nominal KSTAR operating toroidal magnetic field.
Bae Y.S.   +3 more
doaj   +1 more source

Radar Target Recognition Based on Feature Pyramid Fusion Lightweight CNN

open access: yesIEEE Access, 2019
In order to improve the accuracy and robustness of radar target recognition under low SNR conditions, a novel radar high range resolution profile (HRRP) target recognition method based on feature pyramid fusion lightweight CNN is proposed in this paper ...
Chen Guo   +4 more
doaj   +1 more source

From Data Fusion to Knowledge Fusion [PDF]

open access: yes, 2014
The task of {\em data fusion} is to identify the true values of data items (eg, the true date of birth for {\em Tom Cruise}) among multiple observed values drawn from different sources (eg, Web sites) of varying (and unknown) reliability. A recent survey\
Dong, Xin Luna   +6 more
core   +1 more source

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