Results 101 to 110 of about 3,064,989 (321)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Real-time data-driven disruption prediction and its mitigation of MA-plasma experiments in KSTAR with a lower carbon divertor

Nuclear Fusion
Real-time disruption prediction and its mitigation of mega-ampere (MA) plasma experiments have been performed in the 2022 KSTAR carbon lower divertor condition.
Jeongwon Lee, Sang-hee Hahn, Hyunsun Han, Jayhyun Kim, June-Woo Juhn, Jun-Gyo Bak, Jae-in Song, YongUn Nam   +7 more
doaj   +1 more source

Clifford theory for graded fusion categories [PDF]

, 2011
We develop a categorical analogue of Clifford theory for strongly graded rings over graded fusion categories. We describe module categories over a fusion category graded by a group $G$ as induced from module categories over fusion subcategories ...
Galindo, César
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Radar Target Recognition Based on Feature Pyramid Fusion Lightweight CNN

IEEE Access, 2019
In order to improve the accuracy and robustness of radar target recognition under low SNR conditions, a novel radar high range resolution profile (HRRP) target recognition method based on feature pyramid fusion lightweight CNN is proposed in this paper ...
Chen Guo, Haipeng Wang, Tao Jian, You He, Xiaohan Zhang   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Robust Deep Multi-Modal Sensor Fusion using Fusion Weight Regularization and Target Learning

, 2019
Sensor fusion has wide applications in many domains including health care and autonomous systems. While the advent of deep learning has enabled promising multi-modal fusion of high-level features and end-to-end sensor fusion solutions, existing deep ...
Li, Peng, Li, Yang, Shim, Myung Seok, Zhang, Wenrui, Zhang, Xuchong, Zhao, Chenye   +5 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Characterization of a Read-through Fusion Transcript, BCL2L2-PABPN1, Involved in Porcine Adipogenesis [PDF]

, 2022
Jiyuan Zhu, Zewei Yang, Wanjun Hao, Jiaxin Li, Liang Wang, Jiqiao Xia, Dongjie Zhang, Di Liu, Xiuqin Yang   +8 more
openalex   +1 more source