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Fusion-protein-assisted protein crystallization [PDF]
Acta Crystallographica Section F Structural Biology Communications, 2015 Fusion proteins can be used directly in protein crystallization to assist crystallization in at least two different ways. In one approach, the `heterologous fusion-protein approach', the fusion partner can provide additional surface area to promote crystal contact formation.
Kobe, Bostjan +2 more
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Evaluation and Comparison of Clostridium Epsilon-Alpha Fusion Gene Expression Using Different Commercial Expression Vector [PDF]
Archives of Razi Institute, 2021 Clostridium perfringens and Clostridium septicum are gram-positive, anaerobic, spore-forming rods and pathogens for humans and livestock, which are widespread in nature as well as human and animal digestive systems. C.
H. R Sepehrifar +3 more
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Cloning and Expression of a Fusion Protein Containing Highly Epitopic Regions of Clostridium perfringens Epsilon Toxin and Clostridium novyi Alpha Toxin [PDF]
Journal of Cell and Molecular Research, 2021 Clostridium perfringens and novyi species are two important toxin-producing pathogens which pose a risk to the livestock health. Epsilon and alpha toxins are major toxins of these two pathogens, respectively. Advances in current vaccine industrialization
Mohsen Mehrvarz +3 more
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Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein
mBio, 2022 Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean +2 more
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Frontiers in Microbiology, 2022 In ovo vaccination is an attractive immunization strategy for the poultry industry. However, although most live Newcastle disease virus (NDV) vaccine strains, such as LaSota and V4, can be used after hatching, they are pathogenic to chicken embryos when ...
Helong Feng +29 more
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Frontiers in Immunology, 2022 Respiratory Syncytial Virus (RSV) is ubiquitous and re-infection with both subtypes (RSV/A and RSV/B) is common. The fusion (F) protein of RSV is antigenically conserved, induces neutralizing antibodies, and is a primary target of vaccine development ...
Brittani N. Blunck +11 more
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Immune Checkpoints, a Novel Class of Therapeutic Targets for Autoimmune Diseases
Frontiers in Immunology, 2021 Autoimmune diseases, such as multiple sclerosis and type-1 diabetes, are the outcomes of a failure of immune tolerance. Immune tolerance is sustained through interplays between two inter-dependent clusters of immune activities: immune stimulation and ...
Yujia Zhai, Reza Moosavi, Mingnan Chen
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Frontiers in Immunology, 2021 Soft tissue sarcoma (STS) constitutes a rare group of heterogeneous malignancies. Effective treatment options for most subtypes of STS are still limited. As a result, especially in metastatic disease, prognosis is still dismal.
Ilona Hagelstein +23 more
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The FUSION protein crystallization screen
Journal of Applied Crystallography, 2022 The success and speed of atomic structure determination of biological macromolecules by X-ray crystallography depends critically on the availability of diffraction-quality crystals. However, the process of screening crystallization conditions often consumes large amounts of sample and time.
Gorrec, Fabrice, Bellini, Dom
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Evaluation of the Effects of Human Beta-Interferon Scaffold Attachment Region (IFN-SAR) on Expression of Vascular Endothelial Growth Factor-Fc (VEGF-Fc) Fusion Protein Expression in Chinese Hamster Ovary (CHO) Cells [PDF]
Pharmaceutical Sciences, 2020 Background: Recombinant anti-vascular endothelial growth factor (VEGF) monoclonal antibodies and Fc-fusion proteins have been widely used for the effective treatment of retinal neovascular diseases.
Ehsan Naghneh +2 more
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