Results 1 to 10 of about 716,745 (315)
Human opsin restoration by histone methylation using methyltransferase fusion protein SETD7-dCas9. [PDF]
Mol Ther Nucleic AcidsTran NL +7 more
europepmc +2 more sources
OncoImmunology, 2023 Mesothelin (MSLN) is an attractive immuno-oncology target, but the development of MSLN-targeting therapies has been impeded by tumor shedding of soluble MSLN (sMSLN), on-target off-tumor activity, and an immunosuppressive tumor microenvironment.
Daniel Snell +22 more
doaj +1 more source
Evaluation and Comparison of Clostridium Epsilon-Alpha Fusion Gene Expression Using Different Commercial Expression Vector [PDF]
Archives of Razi Institute, 2021 Clostridium perfringens and Clostridium septicum are gram-positive, anaerobic, spore-forming rods and pathogens for humans and livestock, which are widespread in nature as well as human and animal digestive systems. C.
H. R Sepehrifar +3 more
doaj +1 more source
Frontiers in Microbiology, 2022 In ovo vaccination is an attractive immunization strategy for the poultry industry. However, although most live Newcastle disease virus (NDV) vaccine strains, such as LaSota and V4, can be used after hatching, they are pathogenic to chicken embryos when ...
Helong Feng +29 more
doaj +1 more source
Biomedicines, 2022 Ewing sarcoma (EwS), a type of bone and soft tissue tumor, is mainly driven by the expression of the fusion protein EWSR1-FLI1. Upon binding to chromatin, EWSR1-FLI1 reprograms the epigenetic state, alters gene expression, and thus leads to tumorigenesis.
Mingli Li, Chun-Wei Chen
doaj +1 more source
Cloning and Expression of a Fusion Protein Containing Highly Epitopic Regions of Clostridium perfringens Epsilon Toxin and Clostridium novyi Alpha Toxin [PDF]
Journal of Cell and Molecular Research, 2021 Clostridium perfringens and novyi species are two important toxin-producing pathogens which pose a risk to the livestock health. Epsilon and alpha toxins are major toxins of these two pathogens, respectively. Advances in current vaccine industrialization
Mohsen Mehrvarz +3 more
doaj +1 more source
Engineering a New IFN-ApoA-I Fusion Protein with Low Toxicity and Prolonged Action
Molecules, 2023 Recombinant human interferon alpha-2b (rIFN) is widely used in antiviral and anticancer immunotherapy. However, the high efficiency of interferon therapy is accompanied by a number of side effects; this problem requires the design of a new class of ...
Svetlana Miroshnichenko +4 more
doaj +1 more source
Frontiers in Immunology, 2022 Respiratory Syncytial Virus (RSV) is ubiquitous and re-infection with both subtypes (RSV/A and RSV/B) is common. The fusion (F) protein of RSV is antigenically conserved, induces neutralizing antibodies, and is a primary target of vaccine development ...
Brittani N. Blunck +11 more
doaj +1 more source
Molecules, 2023 In the healing of wounds, human-like collagen (hCol) is essential. However, collagen-based composite dressings have poor stability in vivo, which severely limits their current therapeutic potential.
Yingli Chen +9 more
doaj +1 more source
Avian Paramyxovirus Type 1 in Egypt: Epidemiology, Evolutionary Perspective, and Vaccine Approach
Frontiers in Veterinary Science, 2021 Avian orthoavulavirus 1, formerly known as avian paramyxovirus type-1 (APMV-1), infects more than 250 different species of birds. It causes a broad range of clinical diseases and results in devastating economic impact due to high morbidity and mortality ...
Shimaa M. G. Mansour +8 more
doaj +1 more source