Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion
Nature, 2020 Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by virus binding to the ACE2 cell-surface receptors 1 – 4 , followed by fusion of the virus and cell membranes to release the virus genome into the cell.
Steven J Gamblin +2 more
exaly +2 more sources
Pre-fusion structure of a human coronavirus spike protein
Nature, 2016 HKU1 is a human betacoronavirus that causes mild yet prevalent respiratory disease, and is related to the zoonotic SARS and MERS betacoronaviruses, which have high fatality rates and pandemic potential.
Robert N Kirchdoerfer +2 more
exaly +2 more sources
A Novel GLP-1 and FGF21 Fusion Protein for the Treatment of Non-alcoholic Steatohepatitis (NASH) [PDF]
Advanced Pharmaceutical BulletinPurpose: The objective of this study was to develop and produce a novel fusion protein that combines GLP-1 (glucagon-like peptide-1) and FGF21 (fibroblast growth factor 21), with the aim of achieving synergistic pharmacological effects through the ...
Zhipeng Zhang +7 more
doaj +2 more sources
Evaluation and Comparison of Clostridium Epsilon-Alpha Fusion Gene Expression Using Different Commercial Expression Vector [PDF]
Archives of Razi Institute, 2021 Clostridium perfringens and Clostridium septicum are gram-positive, anaerobic, spore-forming rods and pathogens for humans and livestock, which are widespread in nature as well as human and animal digestive systems. C.
H. R Sepehrifar +3 more
doaj +1 more source
Versatile toolbox for high throughput biochemical and functional studies with fluorescent fusion proteins [PDF]
, 2012 Fluorescent fusion proteins are widely used to study protein localization and interaction dynamics in living cells. However, to fully characterize proteins and to understand their function it is crucial to determine biochemical characteristics such as ...
Hake, Sandra B. +3 more
core +20 more sources
Cloning and Expression of a Fusion Protein Containing Highly Epitopic Regions of Clostridium perfringens Epsilon Toxin and Clostridium novyi Alpha Toxin [PDF]
Journal of Cell and Molecular Research, 2021 Clostridium perfringens and novyi species are two important toxin-producing pathogens which pose a risk to the livestock health. Epsilon and alpha toxins are major toxins of these two pathogens, respectively. Advances in current vaccine industrialization
Mohsen Mehrvarz +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Soft tissue sarcoma (STS) constitutes a rare group of heterogeneous malignancies. Effective treatment options for most subtypes of STS are still limited. As a result, especially in metastatic disease, prognosis is still dismal.
Ilona Hagelstein +23 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome. Here, we report that osteosarcoma Rab22a-NeoF1 fusion protein, together with its binding partner PYK2 ...
L. Zhong +13 more
semanticscholar +1 more source
Immune Checkpoints, a Novel Class of Therapeutic Targets for Autoimmune Diseases
Frontiers in Immunology, 2021 Autoimmune diseases, such as multiple sclerosis and type-1 diabetes, are the outcomes of a failure of immune tolerance. Immune tolerance is sustained through interplays between two inter-dependent clusters of immune activities: immune stimulation and ...
Yujia Zhai, Reza Moosavi, Mingnan Chen
doaj +1 more source
Fusion protein strategies for cryo-EM study of G protein-coupled receptors
Nature Communications, 2021 Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine structures of activated G protein-coupled receptors (GPCRs) in complex with G proteins or arrestins. However, applying it to GPCRs without signaling proteins remains
Kaihua Zhang +4 more
semanticscholar +1 more source