Results 171 to 180 of about 1,121,449 (385)
Prot2Chat: Protein LLM with Early Fusion of Sequence and Structure [PDF]
arXivProteins play a pivotal role in living organisms, yet understanding their functions presents significant challenges, including the limited flexibility of classification-based methods, the inability to effectively leverage spatial structural information, and the lack of systematic evaluation metrics for protein Q&A systems. To address these limitations,
arxiv
Molecular Oncology, Volume 19, Issue 4, Page 1229-1243, April 2025.We assessed the associations between the gut microbiota and outcome in metastatic triple‐negative breast cancer patients treated with chemotherapy alone or chemotherapy in combination with immunotherapy. Our data indicate that high gut microbiota alpha diversity was associated with improved clinical outcome and with benefit from immunotherapy.
Andreas Ullern +8 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 4, Page 1170-1187, April 2025.High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies +9 more
wiley +1 more source
An internalized transmembrane protein resides in a fusion-competent endosome for less than 5 minutes. [PDF]
, 1987 Jean Grüenberg, K E Howell
openalex +1 more source
Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley +1 more source
Functional Classification of Fusion Proteins in Sarcoma
CancersSarcomas comprise a heterogeneous group of malignant tumors of mesenchymal origin. More than 80 entities are associated with different mesenchymal lineages. Sarcomas with fibroblastic, muscle, bone, vascular, adipocytic, and other characteristics are distinguished.
Wachtel, Marco +3 more
openaire +3 more sources
Molecular Oncology, Volume 19, Issue 4, Page 1117-1131, April 2025.This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto +3 more
wiley +1 more source
Negative regulation of adenylate cyclase gene (cya) expression by cyclic AMP-cyclic AMP receptor protein in Escherichia coli: studies with cya-lac protein and operon fusion plasmids [PDF]
, 1985 Makoto Kawamukai +5 more
openalex +1 more source
Molecular Oncology, Volume 19, Issue 5, Page 1517-1531, May 2025.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Expression of plant tumor-specific proteins in minicells of Escherichia coli: a fusion protein of lysopine dehydrogenase with chloramphenicol acetyltransferase [PDF]
, 1981 Joachim Schröder +3 more
openalex +1 more source