Results 171 to 180 of about 749,719 (265)

Engineered haptoglobin β fusion protein targets myoglobin and ameliorates rhabdomyolysis-associated acute kidney injury. [PDF]

EMBO Mol Med
Li N, Wang Y, Han L, Qiao O, Wang X, Hao H, Chen X, Wang P, Saeed S, Wang J, Bao F, Hou Y, Zhang L, Duan X, Rao S, Gong Y.   +15 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Fusion protein-mediated costimulation in engineered T cells: from intrinsic signaling to tumor microenvironment rewiring. [PDF]

Front Immunol
Toumi R, Guenette SJ, Oda SK.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Bioorthogonal tuning of nanosurface opsonisation <i>via</i> click coupling of a complement fusion protein inhibitor.

Chem Commun (Camb)
Jacques S, Gaikwad H, Pillatzke J, Moghimi SM, Simberg D.   +4 more
europepmc   +1 more source

Fusion with immunoglobulin Fc fragment enhances the immunogenicity of the African swine fever virus p30/p54 fusion protein. [PDF]

Appl Microbiol Biotechnol
Dang H, Ru Y, Wu G, Hao R, Xu J, Li Y, Zhao D, Jiang C, Han S, Hu X, Wu X, Yang Y, Zheng H.   +12 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

A Brain-Targeted Organophosphorus Hydrolase Fusion Protein Mediated by Angiopep-2 Neutralizes Central Organophosphates and Alleviates Neurotoxicity. [PDF]

Int J Nanomedicine
Xie Y, Zhai Y, Shang J, Ma M, Wang D, Xu S, Ran Y, Li Z, Gao X, Gao J.   +9 more
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Broadly neutralizing nanobodies target a defined structural pivot site on the RSV fusion protein. [PDF]

EMBO Mol Med
Wang Q, Ke X, Li E, Hong D, Cheng Z, Li H, Zhang J, Jin T, Gong R, Shu B, Chiu S.   +10 more
europepmc   +1 more source