Results 241 to 250 of about 1,146,095 (306)

Chromosomal Deletion Involving ANKRD26 Leads to Expression of a Fusion Protein Responsible for ANKRD26-Related Thrombocytopenia. [PDF]

open access: yesInt J Mol Sci
Dell'Orso G   +24 more
europepmc   +1 more source

The APL-associated fusion proteins.

open access: yesHaematologica, 1999
S. Minucci   +3 more
openaire   +2 more sources

Efficacy and safety of the interleukin-10-fragment F8 fusion protein PF-06687234 as add-on therapy to infliximab in patients with active ulcerative colitis: a randomized, phase IIa clinical trial. [PDF]

open access: yesTher Adv Gastroenterol
Schreiber S   +11 more
europepmc   +1 more source

Therapeutic Fusion Proteins

The AAPS Journal, 2023
Therapeutic fusion proteins are a class of hybrid constructs that combine distinct biomolecules into a single platform with the additive effects of the components. The ability to fuse two unrelated proteins provides a means to localize mechanisms to better treat a range of diseases. Fusion proteins can be designed to impart diverse functions, including
Morgan C. Marsh, Shawn C. Owen
openaire   +2 more sources

Fusion proteins form onco-condensates

Nature Structural & Molecular Biology, 2021
A spectrum of high-risk leukemias is caused by recurrent chromosomal translocations that result in the expression of fusion proteins. In a recent article in Nature, it has been demonstrated that the oncogenic properties of one such fusion, NUP98–HOXA9, are linked to its ability to self-associate and function through aberrantly phase-separated “onco ...
Tanja Mittag, Aseem Z. Ansari
openaire   +2 more sources

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