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Development of a Novel Bifunctional Anti-CD47 Fusion Protein with Improved Efficacy and a Favorable Safety Profile. [PDF]

open access: yesMol Cancer Ther
Matar S   +10 more
europepmc   +1 more source

The APL-associated fusion proteins.

open access: yesHaematologica, 1999
S. Minucci   +3 more
openaire   +2 more sources
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Therapeutic Fusion Proteins

The AAPS Journal, 2023
Therapeutic fusion proteins are a class of hybrid constructs that combine distinct biomolecules into a single platform with the additive effects of the components. The ability to fuse two unrelated proteins provides a means to localize mechanisms to better treat a range of diseases. Fusion proteins can be designed to impart diverse functions, including
Morgan C. Marsh, Shawn C. Owen
openaire   +2 more sources

Fusion proteins form onco-condensates

Nature Structural & Molecular Biology, 2021
A spectrum of high-risk leukemias is caused by recurrent chromosomal translocations that result in the expression of fusion proteins. In a recent article in Nature, it has been demonstrated that the oncogenic properties of one such fusion, NUP98–HOXA9, are linked to its ability to self-associate and function through aberrantly phase-separated “onco ...
Tanja Mittag, Aseem Z. Ansari
openaire   +2 more sources

Fusion proteins in biotechnology

Current Opinion in Biotechnology, 1992
Gene fusion techniques allow the production of recombinant proteins featuring the combined characteristics of the parental products. Originally, these techniques were used to probe transcriptional and translational activity, to translocate proteins across cell membranes, and to facilitate the recovery of proteins.
M, Uhlén   +4 more
openaire   +2 more sources

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