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Engineered Prx-LCA2 fusion protein restores oxidative skin damage via enhanced intracellular peroxidase delivery. [PDF]
Liu D +6 more
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Therapeutic vaccination with the Ag85B-Rv2660c-MPT70 fusion protein enhances <i>Mycobacterium tuberculosis</i> H37Ra clearance in post-exposure mice. [PDF]
Hu Z +8 more
europepmc +1 more source
Development of a trispecific fusion protein based on angiotensin-converting enzyme 2, glycoprotein 130, and tumor necrosis factor receptor 2 as a promising therapeutic for COVID-19. [PDF]
Qiao Y +19 more
europepmc +1 more source
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2016
Albumin fusion technology can improve the blood retention properties of protein-based pharmaceutics that have a short circulation half-life. The procedure consists of fusing the HSA gene with the gene for a therapeutic protein or peptide, thus permitting the existing recombinant protein therapeutics to be reengineered using albumin as a suitable and ...
Toru Maruyama +2 more
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Albumin fusion technology can improve the blood retention properties of protein-based pharmaceutics that have a short circulation half-life. The procedure consists of fusing the HSA gene with the gene for a therapeutic protein or peptide, thus permitting the existing recombinant protein therapeutics to be reengineered using albumin as a suitable and ...
Toru Maruyama +2 more
openaire +2 more sources
The AAPS Journal, 2023
Therapeutic fusion proteins are a class of hybrid constructs that combine distinct biomolecules into a single platform with the additive effects of the components. The ability to fuse two unrelated proteins provides a means to localize mechanisms to better treat a range of diseases. Fusion proteins can be designed to impart diverse functions, including
Morgan C. Marsh, Shawn C. Owen
openaire +2 more sources
Therapeutic fusion proteins are a class of hybrid constructs that combine distinct biomolecules into a single platform with the additive effects of the components. The ability to fuse two unrelated proteins provides a means to localize mechanisms to better treat a range of diseases. Fusion proteins can be designed to impart diverse functions, including
Morgan C. Marsh, Shawn C. Owen
openaire +2 more sources
Fusion proteins form onco-condensates
Nature Structural & Molecular Biology, 2021A spectrum of high-risk leukemias is caused by recurrent chromosomal translocations that result in the expression of fusion proteins. In a recent article in Nature, it has been demonstrated that the oncogenic properties of one such fusion, NUP98–HOXA9, are linked to its ability to self-associate and function through aberrantly phase-separated “onco ...
Tanja Mittag, Aseem Z. Ansari
openaire +2 more sources
Fusion proteins in biotechnology
Current Opinion in Biotechnology, 1992Gene fusion techniques allow the production of recombinant proteins featuring the combined characteristics of the parental products. Originally, these techniques were used to probe transcriptional and translational activity, to translocate proteins across cell membranes, and to facilitate the recovery of proteins.
M, Uhlén +4 more
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