Results 31 to 40 of about 494,811 (167)

The Hemagglutinin-Neuraminidase (HN) Head Domain and the Fusion (F) Protein Stalk Domain of the Parainfluenza Viruses Affect the Specificity of the HN-F Interaction

Frontiers in Microbiology, 2018
Membrane fusion by the parainfluenza viruses is induced by virus-specific functional interaction between the attachment protein (HN) and the fusion (F) protein.
Masato Tsurudome, Junpei Ohtsuka, Morihiro Ito, Machiko Nishio, Tetsuya Nosaka   +4 more
doaj   +1 more source

Engineering a New IFN-ApoA-I Fusion Protein with Low Toxicity and Prolonged Action

Molecules, 2023
Recombinant human interferon alpha-2b (rIFN) is widely used in antiviral and anticancer immunotherapy. However, the high efficiency of interferon therapy is accompanied by a number of side effects; this problem requires the design of a new class of ...
Svetlana Miroshnichenko, Mariya Pykhtina, Anastasiia Kotliarova, Alexander Chepurnov, Anatoly Beklemishev   +4 more
doaj   +1 more source

Regional perturbation of gene transcription is associated with intrachromosomal rearrangements and gene fusion transcripts in high grade ovarian cancer. [PDF]

, 2019
Genomic rearrangements are a hallmark of cancer biology and progression, allowing cells to rapidly transform through alterations in regulatory structures, changes in expression patterns, reprogramming of signaling pathways, and creation of novel ...
Beck, Tim, E Francis, Kyle, Krzyzanowski, Paul, La Rose, Jose, McPherson, John, Normand, Josee, Rottapel, Robert, Sircoulomb, Fabrice, Stein, Lincoln, Suarez, Fernando, Yousif, Fouad   +10 more
core   +2 more sources

Molecular Dynamics Simulation Reveals Exposed Residues in the Ligand-Binding Domain of the Low-Density Lipoprotein Receptor that Interacts with Vesicular Stomatitis Virus-G Envelope

Viruses, 2019
Familial hypercholesterolemia (FH) is an autosomal dominant disease most often caused by mutations in the low-density lipoprotein receptor (LDLR) gene, which consists of 18 exons spanning 45 kb and codes for a precursor protein of 860 amino acids ...
Faisal A. Al-Allaf, Zainularifeen Abduljaleel, Mohiuddin M. Taher, Ahmed A. H. Abdellatif, Mohammad Athar, Neda M. Bogari, Mohammed N. Al-Ahdal, Futwan Al-Mohanna, Zuhair N. Al-Hassnan, Kamal H. Y. Alzabeedi, Talib M. Banssir, Abdellatif Bouazzaoui   +11 more
doaj   +1 more source

Synthetic protein scaffolds based on peptide motifs and cognate adaptor domains for improving metabolic productivity

Frontiers in Bioengineering and Biotechnology, 2015
The efficiency of many cellular processes relies on the defined interaction among different proteins within the same metabolic or signaling pathway. Consequently, a spatial colocalization of functionally interacting proteins has frequently emerged during
Anselm H.C. Horn, Heinrich eSticht
doaj   +1 more source

Epigenetic and Transcriptional Signaling in Ewing Sarcoma—Disease Etiology and Therapeutic Opportunities

Biomedicines, 2022
Ewing sarcoma (EwS), a type of bone and soft tissue tumor, is mainly driven by the expression of the fusion protein EWSR1-FLI1. Upon binding to chromatin, EWSR1-FLI1 reprograms the epigenetic state, alters gene expression, and thus leads to tumorigenesis.
Mingli Li, Chun-Wei Chen
doaj   +1 more source

ViralFP: A webserver of viral fusion proteins [PDF]

arXiv, 2021
Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the host cell.
arxiv  

Antigenic Site-Specific Competitive Antibody Responses to the Fusion Protein of Respiratory Syncytial Virus Were Associated With Viral Clearance in Hematopoietic Cell Transplantation Adults

Frontiers in Immunology, 2019
Background: Recent studies of human sera showed that the majority of the respiratory syncytial virus (RSV) neutralizing antibodies are directed against pre-fusion conformation of the fusion (F) protein of RSV and revealed the importance of pre-fusion ...
Xunyan Ye, Obinna P. Iwuchukwu, Vasanthi Avadhanula, Letisha O. Aideyan, Trevor J. McBride, Laura L. Ferlic-Stark, Kirtida D. Patel, Felipe-Andres Piedra, Dimpy P. Shah, Roy F. Chemaly, Pedro A. Piedra, Pedro A. Piedra   +11 more
doaj   +1 more source

An engineered T-cell engager with selectivity for high mesothelin-expressing cells and activity in the presence of soluble mesothelin

OncoImmunology, 2023
Mesothelin (MSLN) is an attractive immuno-oncology target, but the development of MSLN-targeting therapies has been impeded by tumor shedding of soluble MSLN (sMSLN), on-target off-tumor activity, and an immunosuppressive tumor microenvironment.
Daniel Snell, Tea Gunde, Stefan Warmuth, Bithi Chatterjee, Matthias Brock, Christian Hess, Maria Johansson, Alexandre Simonin, Fabio Mario Spiga, Christopher Weinert, Niels Kirk, Nicole Bassler, Lucia Campos Carrascosa, Naomi Flückiger, Robin Heiz, Sandro Wagen, Noreen Giezendanner, Alessandra Alberti, Yasemin Yaman, Dana Mahler, Dania Diem, Peter Lichtlen, David Urech   +22 more
doaj   +1 more source

Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor [PDF]

, 1996
The N-methyl-D-aspartate (NMDA) subtype of excitatory glutamate receptors plays critical roles in embryonic and adult synaptic plasticity in the central nervous system.
Alan J. Rosenstein, Boyle, Carlin, Cho, Dudek, Dudek, Goldenring, Grieco, Hollmann, Ishii, Kelly, Kennedy, Kennedy, Kennedy, Kindler, Kohler, Kornau, Kyung-Tai Min, Laemmli, Lieberman, Lynch, Malenka, Mary B. Kennedy, Mayer, Mayer, Mayford, McGlade-McCulloh, Melinda J. Kiely, Miller, Miller, Molloy, Monyer, Moon, Morris, Nakanishi, Nowak, Patton, Pearson, Peterson, Pettit, Podell, Ramakrishnapillai V. Omkumar, Raman, Seeburg, Silva, Smith, Squire, Stevens, Tingley, Wang, Wang, Watterson   +51 more
core   +1 more source