Results 31 to 40 of about 7,427,824 (408)
Immune Checkpoints, a Novel Class of Therapeutic Targets for Autoimmune Diseases
Frontiers in Immunology, 2021 Autoimmune diseases, such as multiple sclerosis and type-1 diabetes, are the outcomes of a failure of immune tolerance. Immune tolerance is sustained through interplays between two inter-dependent clusters of immune activities: immune stimulation and ...
Yujia Zhai, Reza Moosavi, Mingnan Chen
doaj +1 more source
Cyanobacterial Production of Biopharmaceutical and Biotherapeutic Proteins
Frontiers in Plant Science, 2020 Efforts to express human therapeutic proteins in photosynthetic organisms have been described in the literature. Regarding microalgae, most of the research entailed a heterologous transformation of the chloroplast, but transformant cells failed to ...
Nico Betterle +2 more
doaj +1 more source
Frontiers in Immunology, 2021 Soft tissue sarcoma (STS) constitutes a rare group of heterogeneous malignancies. Effective treatment options for most subtypes of STS are still limited. As a result, especially in metastatic disease, prognosis is still dismal.
Ilona Hagelstein +23 more
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Expression in Escherichia coli of a cloned DNA sequence encoding the pre-S2 region of hepatitis B virus [PDF]
, 1985 A DNA sequence encoding the entire pre-S2 region (amino acids 120-174; serotype ayw) of human hepatitis B virus envelope protein has been inserted into the lacZ gene of the plasmid pSKS105 yielding a recombinant, pWS3.
Acs, George +7 more
core +1 more source
Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
Cellular & Molecular Immunology, 2020 Very recently, a novel coronavirus, 2019-nCoV, emerged in Wuhan, China and then quickly spread worldwide, resulting in >17,388 confirmed cases and 361 deaths as of 3 February 2020, thus calling for the development of safe and effective therapeutics and ...
Shuai Xia +10 more
semanticscholar +1 more source
ATP-independent Control of Vac8 Palmitoylation by a SNARE Subcomplex on Yeast Vacuoles [PDF]
, 2005 Yeast vacuole fusion requires palmitoylated Vac8. We previously showed that Vac8 acylation occurs early in the fusion reaction, is blocked by antibodies against Sec18 (yeast N-ethylmaleimide-sensitive fusion protein (NSF)), and is mediated by the R-SNARE
Cristodero, Marina +5 more
core +1 more source
A Novel GLP-1 and FGF21 Fusion Protein for the Treatment of Non-alcoholic Steatohepatitis (NASH) [PDF]
Advanced Pharmaceutical BulletinPurpose: The objective of this study was to develop and produce a novel fusion protein that combines GLP-1 (glucagon-like peptide-1) and FGF21 (fibroblast growth factor 21), with the aim of achieving synergistic pharmacological effects through the ...
Zhipeng Zhang +7 more
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Fermentation, 2023 Phycocyanobilin (PCB) is the bioactive chromophore attached to Phycocyanin (PC) that is of special interest for nutraceutical and therapeutic applications. However, the production of PCB from the heterologous host Escherichia coli is still very low.
Xiaolin Liu +5 more
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Protein-Protein Fusion Catalyzed by Sortase A
PLoS ONE, 2011 Chimeric proteins boast widespread use in areas ranging from cell biology to drug delivery. Post-translational protein fusion using the bacterial transpeptidase sortase A provides an attractive alternative when traditional gene fusion fails. We describe use of this enzyme for in vitro protein ligation and report the successful fusion of 10 pairs of ...
Ranganath Parthasarathy +3 more
openaire +5 more sources
Antioxidants, 2021 Methionine sulfoxide reductase (Msr) is a family of enzymes that reduces oxidized methionine and plays an important role in the survival of bacteria under oxidative stress conditions.
Sulhee Kim +6 more
doaj +1 more source