Results 31 to 40 of about 36,628 (255)

Fusobacterium is associated with colorectal adenomas. [PDF]

PLoS ONE, 2013
The human gut microbiota is increasingly recognized as a player in colorectal cancer (CRC). While particular imbalances in the gut microbiota have been linked to colorectal adenomas and cancer, no specific bacterium has been identified as a risk factor ...
Amber N McCoy, Félix Araújo-Pérez, Andrea Azcárate-Peril, Jen Jen Yeh, Robert S Sandler, Temitope O Keku   +5 more
doaj   +1 more source

Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria. [PDF]

Cancer Sci
Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Ren M, Jia J, Li T, Li Y, Shen N, Shi Y, Wang Z, Fan H, Sun G, Xiong G, Li G, Peng R.   +11 more
europepmc   +2 more sources

Fusobacterium nucleatum [PDF]

Gut Microbes, 2011
The Gram-negative, non-sporulating, obligately anaerobic species, Fusobacterium nucleatum, is rapidly gaining notoriety as a pathogen with a surprising number of associated diseases. Recently, we have found that F. nucleatum is a more common resident of the GI tract than originally thought, and thus, through several studies, we have attempted to ...
Emma, Allen-Vercoe, Jaclyn, Strauss, Kris, Chadee   +2 more
openaire   +2 more sources

Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients

npj Biofilms and Microbiomes, 2022
Perturbations in the gut microbiome have been associated with colorectal cancer (CRC), with the colonic overabundance of Fusobacterium nucleatum shown as the most consistent marker.
Hoang N. H. Tran, Trang Nguyen Hoang Thu, Phu Huu Nguyen, Chi Nguyen Vo, Khanh Van Doan, Chau Nguyen Ngoc Minh, Ngoc Tuan Nguyen, Van Ngoc Duc Ta, Khuong An Vu, Thanh Danh Hua, To Nguyen Thi Nguyen, Tan Trinh Van, Trung Pham Duc, Ba Lap Duong, Phuc Minh Nguyen, Vinh Chuc Hoang, Duy Thanh Pham, Guy E. Thwaites, Lindsay J. Hall, Daniel J. Slade, Stephen Baker, Vinh Hung Tran, Hao Chung The   +22 more
doaj   +1 more source

Vitamin D deficiency in mice modulates oral microbiome stability over time and leads to changes in host inflammatory gene expression pathways

Frontiers in Cellular and Infection Microbiology
IntroductionWe previously showed that vitamin D deficiency leads to gingival inflammation and alveolar bone loss in mice, and that topical vitamin D3 administration prevents that bone loss and inflammation and fosters a health-associated oral microbiota ...
Lisa Kathleen Ryan, Lisa Kathleen Ryan, Ana E. Duran-Pinedo, Daniel W. Irelan, Braden Mulcahy, Michelle Galeas-Pena, Sarah C. Glover, Jorge Frias-Lopez, Gill Diamond, Gill Diamond   +9 more
doaj   +1 more source

A case report of mesenteric and portal vein thrombosis in a patient with Fusobacterium nucleatum bacteremia

Thrombosis Update, 2021
Background: Fusobacterium bacteria are fastidious commensals in the human oropharyngeal microbiome. As pathogens, Fusobacterium are associated with diverse infectious and inflammatory conditions, including Lemierre's syndrome, colorectal cancer, and ...
Aaron N. Cheng, Jamie O. Brett, Jaspreet Sandhu, Lucy Morse, Rebecca Liu, Junsung Rho, Victor Chiappa, Kathy M. Tran   +7 more
doaj   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source