bacNeo: A Computational Toolkit for Identifying Bacteria‐Derived Neoantigens in Human Cancers
We present bacterial neoantigen (bacNeo), a multi‐omics‐based computational software to classify bacterial components (BACC), type bacteria‐bound HLA alleles (BACH), and prioritize bacterial peptides as neoantigens (BACP). Bacterial neoantigen potential is quantified by score for peptide antigenicity recognition & kinetics (SPARK), enabling ...
Yunzhe Wang +5 more
wiley +1 more source
<i>Fusobacterium nucleatum</i> Lipopolysaccharides Disrupt the Interaction of Siglec‑7 to Sialoglycans Expressed on Mammalian Cells. [PDF]
Gumah Adam Ali M +11 more
europepmc +1 more source
Fusobacterium nucleatum Enhances Intestinal Adaptation of Vibrio cholerae via Interspecies Biofilm Formation. [PDF]
Chen G, Chen J, Wang X, Guo D, Liu Z.
europepmc +1 more source
Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases
The oral microbiome undergoes dynamic establishment from birth, maturing into a resilient ecosystem. Perturbation of this homeostasis—driven by dietary, immunological, and anatomical factors—triggers dysbiosis, which underpins the pathogenesis of major oral diseases, including dental caries, periodontal disease, salivary gland disorders, oral mucosal ...
Zixi Kang +8 more
wiley +1 more source
Beyond a single species: Mapping virulence traits across the redefined <i>Fusobacterium nucleatum</i> complex. [PDF]
Wolf M +7 more
europepmc +1 more source
Gut microbiome plays a crucial role in colorectal cancer development. The advanced sequencing techniques have the potential to complement current non‐invasive methods for early diagnosis and prevention of colorectal cancer. This includes conducting studies with robust statistical power and consistent, replicable methodologies, taking into consideration
Parvin Askari +10 more
wiley +1 more source
Reprogramming of pathogenic strategies in <i>Fusobacterium nucleatum</i>: a study based on an <i>in vitro</i> infection model. [PDF]
Ma L +6 more
europepmc +1 more source
ABSTRACT The growing recognition of the microbiome’s role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai +6 more
wiley +1 more source
The role of <i>Fusobacterium nucleatum</i> in the tumour microenvironment and carcinogenesis of oral and colonic malignancies. [PDF]
Larionova E, Moran GP.
europepmc +1 more source
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu +6 more
wiley +1 more source

