Results 61 to 70 of about 33,412 (306)
Advanced Science, EarlyView.Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong +12 more
wiley +1 more source
Gut Pathogens, 2022 Background Acute liver failure (ALF) patients are often accompanied by severe energy metabolism abnormalities and intestinal microecological imbalance. The intestinal mucosal barrier is severely damaged.
Pan Cao +4 more
doaj +1 more source
Advanced Science, EarlyView.The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu +13 more
wiley +1 more source
Jurnal Kedokteran Gigi Universitas Padjadjaran, 2022 ABSTRAK Pendahuluan: Prevalensi periodontitis di Indonesia masih terbilang tinggi. Data Riskesdas 2018 menunjukkan persentase kasus periodontitis di Indonesia sebesar 74,1%.
Zahara Meilawaty +5 more
doaj +1 more source
A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche
NatureFusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy individuals1, is enriched in human colorectal cancer (CRC) tumours2–5.
Martha A. Zepeda-Rivera +21 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao +18 more
wiley +1 more source
Journal of Oral Microbiology, 2023 Background Endodontic infections are known to be caused by pathogenic bacteria. Numerous previous studies found that both Fusobacterium nucleatum and Enterococcus faecalis are associated with endodontic infections, with Fusobacterium nucleatum more ...
Doudou Xiang +8 more
doaj +1 more source
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer.
Cancer CellMicrosatellite stable (MSS) colorectal cancers (CRCs) are often resistant to anti-programmed death-1 (PD-1) therapy. Here, we show that a CRC pathogen, Fusobacterium nucleatum (Fn), paradoxically sensitizes MSS CRC to anti-PD-1.
Xueliang Wang +23 more
semanticscholar +1 more source
International Journal of Oral Science, 2023 Fusobacterium nucleatum ( F. nucleatum ) is an early pathogenic colonizer in periodontitis, but the host response to infection with this pathogen remains unclear. In this study, we built an F.
Yushang Wang +10 more
semanticscholar +1 more source
Advanced Science, EarlyView.This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu +8 more
wiley +1 more source