Results 81 to 90 of about 17,845 (237)

Enrichment of T: A→A: T substitutions in the TP53 gene in esophageal carcinoma with high Fusobacterium burden

Scientific Reports
Exogenous lifestyle and environmental risk factors impact mutation burden in both benign and cancerous tissues. Moreover, interactions between the mucosa-associated microbiome and such genotoxic changes have been implicated in several cancer types.
Tomomitsu Tahara, Takuya Shijimaya, Jumpei Yamazaki, Tsubasa Shimogama, Sanshiro Kobayashi, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Toshiro Fukui, Tomoyuki Shibata, Makoto Naganuma   +10 more
doaj   +1 more source

The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management

Chronic Diseases and Translational Medicine, 2019
Colorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue; many studies have indicated that F.
Chun-Hui Sun, Bin-Bin Li, Bo Wang, Jing Zhao, Xiao-Ying Zhang, Ting-Ting Li, Wen-Bing Li, Di Tang, Miao-Juan Qiu, Xin-Cheng Wang, Cheng-Ming Zhu, Zhi-Rong Qian   +11 more
doaj   +1 more source

Fusobacterium Nucleatum and Meningitis

Scholars Journal of Medical Case Reports
Fusobacterium nucleatum is a rare cause of meningitis in adults, yet it is associated with significant morbidity and mortality. We present a case of meningitis due to Fusobacterium nucleatum in a 28-year-old male with a history of head trauma two years prior, recurrent pneumococcal meningitis, and a cerebrospinal fluid leak. Initial cerebrospinal fluid
Ngindu M. Filston, Khaleq Khalid, Dibwe K. Glodi, Kamate Oumar   +3 more
openaire   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

Fusobacterium nucleatum, the communication with colorectal cancer

Biomedicine & Pharmacotherapy, 2019
Colorectal cancer (CRC) is the fourth most common cancer in 2018 with poor prognosis. Fusobacterium nucleatum (F.n), an anaerobe, is found to be enriched in both stools and tumor tissues of CRC patients. As surveys show, tumor initiates before the collection of F.n.
Kangjia, Luo, Yvkun, Zhang, Chao, Xv, Jingjing, Ji, Ge, Lou, Xiaorong, Guo, Meilun, Chen, Yingjie, Zhang, Huiying, Wei, Mian, Guo, Rui, Huang, Shan, Yu   +11 more
openaire   +2 more sources

Zinc‐stabilized stannous fluoride modulates the periodontal microbiome, reducing Fusobacteria, key Gram‐negative species, and overall inflammation within an experimental gingivitis clinical trial

Journal of Periodontology, EarlyView.
Abstract Background This study aimed to evaluate the effects of a dentifrice containing stannous fluoride stabilized with zinc phosphate on subgingival microbiome composition and clinical inflammation during experimental gingivitis, compared with a sodium fluoride control. Methods This investigation was conducted as a secondary analysis of a randomized,
Kristopher A. Kerns, Allison A. Naumann, Lay Y. Soon, Erik L. Hendrickson, Abdelahhad Barbour, Dandan Chen, Harsh M. Trivedi, Michael Glogauer, Jeffrey S. McLean   +8 more
wiley   +1 more source

Full-length 16S rRNA nanopore sequencing enables species resolution of Fusobacterium associated with colorectal cancer

Gut Microbes
Recent studies have revealed that the long-recognized link between the historically defined Fusobacterium nucleatum group and colorectal cancer is largely driven by Fusobacterium animalis.
William Rosenbaum, Marina Rubio Garcia, Anna Löfgren-Burström, Pär Larsson, Sofia Edin, Vicky Bronnec, Richard Palmqvist   +6 more
doaj   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source

Fusobacterium nucleatum Infection Drives Glutathione Depletion in Gastric Cancer: Integrated Multi-Omics and Experimental Validation

Microorganisms
The colonization of Fusobacterium nucleatum (F. nucleatum) in the microenvironment of gastric cancer (GC) is closely associated with tumor progression, but its impact on host metabolic remodeling remains unclear.
Siru Nie, Yuehua Gong, Ang Wang, Rui Guo, Xiaohui Chen, Yuan Yuan   +5 more
doaj   +1 more source

Fusobacterium nucleatumand colorectal cancer: A review

World Journal of Gastrointestinal Oncology, 2018
Fusobacterium nucleatum (F. nucleatum) is a Gram-negative obligate anaerobe bacterium in the oral cavity and plays a role in several oral diseases, including periodontitis and gingivitis. Recently, several studies have reported that the level of F.
Shang, Fu-Mei, Liu, Hong-Li
openaire   +2 more sources